A Developmental History of the Positive and Negative Syndrome Scale (PANSS)

| December 1, 2017 | 0 Comments

by Stacy Liechti, PhD; Gianna Capodilupo, MA; Douglas J. Opler, MD; Mark Opler, PhD, MPH; and Lawrence H. Yang, PhD

Dr. Liechti is Lead Research Consultant at the PANSS Institute in New York, New York. Ms. Capodilupo is Research Assistant at MedAvante-ProPhase in New York, New York. Dr. D. Opler is Assistant Professor in the Department of Psychiatry at Rutgers New Jersey Medical School in Newark, New Jersey. Dr. Opler is Adjunct Assistant Professor at NYU School of Medicine and Chief Research Officer at MedAvante-ProPhase Inc. in New York, New York. Dr. Yang is Associate Professor of Social and Behavioral Sciences at New York University in New York, New York.

Funding: No funding was provided for this article.

Disclosures: The authors have no financial conflicts relevant to the content of this article.

Abstract: Psychometric instruments are products of their time— Their designs and initial purposes are influenced and shaped by the contemporary treatment regimens, context, and cultural and conceptual biases of their developers. In this review article, the authors explore the history of the most influential schizophrenia research tools that have been created over the past several decades. The authors describe the scientific concepts, cultural influences, and challenges of past and present researchers as they strive to develop better assessment tools for schizophrenia. Starting with Moore’s Scheme for the Quantitative Measurement of Abnormal Emotional Condition, developed in the early 1900s, and concluding with Kay, Fiszbein, and Opler’s Positive and Negative Syndrome Scale, developed in the 80s, the authors describe several scales and illustrate how each scale led to and influenced the development of a later scale. The authors hope that a better understanding of schizophrenia assessment tool evolution and limitations will assist in the development of new instruments that better address the global needs for the evaluation, research, and treatment of psychosis. 

Keywords: Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS), Inpatient Multidimensional Psychiatric Scale (IMPS), Multidimensional Scale for Rating Psychiatric Patients (MSRPP), psychometrics, symptoms, psychosis

Innov Clin Neurosci. 2017;14(11–12):12–17


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Category: Assessment Tools, Drug Development, Past Articles, Patient Assessment, Psychiatry, Psychopharmacology, Review, Scales, Schizophrenia, Trial Methodology

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