Innov Clin Neurosci. 2024;21(4–6):8–10.

Funding/financial disclosures. The authors have no conflicts of interest relevant to the contents of this letter. No funding was received for the preparation of this letter.

Dear Editor:

We would like to comment on “ChatGPT and Transcranial Direct Current Stimulation for Chronic Pain.”1 The purpose of this study was to investigate how artificial intelligence (AI), more specifically ChatGPT, might be used in conjunction with transcranial direct current stimulation (tDCS) to manage chronic pain. To help direct the conversation, three main questions were developed, and ChatGPT’s answers were contrasted with previously published materials, including Cochrane reviews and guidelines. The results point to a prospective role for AI in transforming neuromodulation research and academic practices, and they also show that AI can help clinicians and researchers in this field.

The study’s approach might be flawed, since it only uses ChatGPT-generated responses to compare to the reviews and guidelines. Even though this AI tool can offer insightful information, its answers might not always correctly reflect industry best practices. Furthermore, the study makes no reference to any expert commentary or qualitative analysis to support the ChatGPT findings, which could have offered a more thorough and nuanced viewpoint on the subject.

The lack of a thorough examination of the difficulties and constraints associated with incorporating AI in the context of tDCS for chronic pain management is a weakness in this topic. When implementing AI in clinical and scientific contexts, it is crucial to take potential biases, ethical issues, and the accuracy of the information produced by the technology into account. These concerns should be the focus of future research to guarantee the ethical and successful adoption of AI in medical procedures.

Research in this field might go in this direction in the future by performing empirical investigations to verify the insights produced by AI tools such as ChatGPT. Working together, neuromodulation researchers, physicians, and AI specialists can improve the use of AI in clinical decision support and scientific research. Furthermore, it would be beneficial to look into how AI might be used to tailor tDCS treatments to specific patients according to their individual pain profiles in the future. Through the resolution of these methodological and conceptual obstacles, the sector may fully utilize AI to enhance chronic pain management results. Furthermore, because ChatGPT output is totally dependent on commands from human users, human user behavior code is required.2


  1. Silva-Filho E, Pegado R. ChatGPT and transcranial direct current stimulation for chronic pain. Innov Clin Neurosci. 2024;21(1–3):61–62.
  2. Kleebayoon A, Wiwanitkit V. ChatGPT, critical thing and ethical practice. Clin Chem Lab Med. 2023;61(11):e221.

With regards,

Hinpetch Daungsupawong, PhD, and Viroj Wiwanitkit, MD

Dr. Daungsupawong is a Private Academic Consultant in Phonhong, Lao People’s Democratic Republic. Dr. Wiwanitkit is with Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University in Chennai, India.

Author contributions. HD: Ideas, writing, analyzing, approval; VW: Ideas, supervision, approval.