Innovations in Clinical Neuroscience

Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 19, ISSUE 10–12, OCTOBER-DECEMBER 2022

Letter to the Editor: Olanzapine-induced Endoplasmic Reticulum Stress Induces Atypical Diabetes and Diabetic Ketoacidosis

Letter to the Editor: Olanzapine-induced Endoplasmic Reticulum Stress Induces Atypical Diabetes and Diabetic Ketoacidosis

Funding/financial disclosures. The author has no conflicts of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(10–12):8–9. Dear Editor: Patients exposed to second-generation antipsychotics (SGAs) are at approximately 10 times greater risk of developing diabetic ketoacidosis (DKA), compared to the general population.1 […]

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Major Depressive Disorder, Suicides, and the Role of Dimensional Psychiatry for Triaging in Primary Care Settings: A Case Series Retroanalysis

Major Depressive Disorder, Suicides, and the Role of Dimensional Psychiatry for Triaging in Primary Care Settings: A Case Series Retroanalysis

by Atmaram Yarlagadda, MD; Adrian R. Johnson, LCSW, MSW; Cheyenne M. Bickerstaff, BS; Joseph R. Yancey, MD, MBA; Samuel L. Preston, DO; Liquori L. Etheridge, LCSW; Michelle Maddalozzo, LCSW; Samuel Ochinang, LCSW; Rosemary A. Jackson, DNP, PMHNP-BC; and Anita H. Clayton, MD Dr. Yarlagadda is Installation Director of Psychological Health at McDonald Army Health Center in Fort Eustis, […]

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Executive Functioning in Children and Adolescents with ADHD and Disruptive Behavior Disorders

Executive Functioning in Children and Adolescents with ADHD and Disruptive Behavior Disorders

by Rosa Elena Ulloa Flores, MD, PhD; Ricardo Díaz Sánchez, BS;  Francisco R. de la Peña, MD, MS; Marcos F. Rosetti Sciutto, PhD; Lino Palacios Cruz, MD, PhD; and Pablo Mayer Villa, MD, MS  Dr. Ulloa Flores is with Hospital Psiquiátrico Infantil Dr. Juan N. Navarro, in México City, México. Mr. Díaz Sánchez is with Arete […]

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PAST ARTICLES

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

by Muhannad M. Alsharidah, MBBS; Mohammad Uzair, BS; Sarah S. Alseneidi, MBBS; Afnan A. Alkharan, MBBS; Reem Fahd Bunyan, MBBS; and Shahid Bashir, PhD Drs. Alsharidah and Alseneidi are with the College of Medicine, King Saud University in Riyadh, Saudi Arabia. Mr. Uzair is with the Department of Biological Sciences, Faculty of Basic and Applied […]

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Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single  Case Pilot Study on a Novel Neuromodulation Approach

Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation Approach

by Antonino Naro, MD, PhD; Luana Billeri, MSc; Paola Lauria, MSc; Alfredo Manuli, MSc; and Rocco Salvatore Calabrò, MD  Drs. Naro and Calabrò, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS Centro Neurolesi Bonino Pulejo–Piemonte in Messina, Italy. Funding: No funding was provided for this study.   Disclosures: The authors have no conflicts […]

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Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

by Loredana Raciti, MD, PhD; Francesca Antonia Arcadi, MD, PhD; and Rocco Salvatore Calabrò, MD, PhD Drs. Raciti, Arcadi, and Calabrò are with IRCCS Centro Neurolesi “Bonino Pulejo” in Messina, Italy. Funding: No funding was provided for this study.   Disclosures: The authors have no conflicts of interest relevant to the content of this article.  Innov […]

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PSYCHOTHERAPY ROUNDS

Psychotherapy for Adult ADHD

Psychotherapy for Adult ADHD

by Kari Harper, MD, and Julie P. Gentile, MD, MBA Dr. Harper is Assistant Professor and Dr. Gentile is Professor and Chair of the Department of Psychiatry at Wright State University in Dayton, Ohio.  Funding: No funding was provided for this study. Disclosures: The authors have no conflicts of interest relevant to the content of […]

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Personality Disorders in Patients with Intellectual Disability

Personality Disorders in Patients with Intellectual Disability

by Julie P. Gentile MD, MBA; Nita V. Bhatt MD, MPH; Jesse P. Cannella, BS; Kari Harper, MD; and John Johnson, MD, MBA Dr. Gentile is Professor and Chair of the Department of Psychiatry at Wright State University in Dayton, Ohio. Dr. Bhatt is Associate Professor and Associate Clerkship Director at Wright State University in […]

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Psychotherapy for Violent Behavior in Children and Adolescents

Psychotherapy for Violent Behavior in Children and Adolescents

by Kari Harper, MD, and Julie P. Gentile, MD, MBA Dr. Harper is Assistant Professor and Assistant Training Director of Child/Adolescent Fellowship at Wright State University in Dayton, Ohio. Dr. Gentile is Professor and Chair of the Department of Psychiatry at Wright State University in Dayton, Ohio. Funding: No funding was provided for this study. […]

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Schizophrenia

Xanomeline and Trospium: A Potential Fixed Drug Combination (FDC) for Schizophrenia—A Brief Review of Current Data

Xanomeline and Trospium: A Potential Fixed Drug Combination (FDC) for Schizophrenia—A Brief Review of Current Data

by Alok Singh, MD Dr. Singh is with All India Institute of Medical Sciences in Raipur, India. Funding: No funding was provided for this study. Disclosures: The author has no conflicts of interest relevant to the contents of this article. Innov Clin Neurosci. 2022;19(10–12):43–47. Abstract Xanomeline, a cholinergic agonist, was initially evaluated for the treatment […]

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Impact of Lurasidone on Metabolic Parameters and Prolactin Levels Based on Differences of Psychiatric Diagnosis, Dosage, and Introducing Methods: An Observational Study

Impact of Lurasidone on Metabolic Parameters and Prolactin Levels Based on Differences of Psychiatric Diagnosis, Dosage, and Introducing Methods: An Observational Study

by Masaru Nakamura, MD, PhD, and Takahiko Nagamine, MD, PhD Dr. Nakamura is with the Department of Psychiatric Internal Medicine, Kosekai-Kusatsu Hospital in Hiroshima, Japan. Dr. Nagamine is with the Department of Psychiatric Internal Medicine, Sunlight Brain Research Center in Yamaguchi, Japan. Funding: No funding was provided for this study.  Disclosures: The authors have no […]

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Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

by JP Lindenmayer, MD; Beverly J. Insel, PhD; Anzalee Khan, PhD; McKenzie Osborne, BA; Abraham Goldring, MA; and Mary Seddo, BA Drs. Lindenmayer, Insel, and Khan, Ms. Osborne and Seddo, and Mr. Goldring are with Manhattan Psychiatric Center in New York City, New York. Drs. Lindenmayer and Khan and Mr. Goldring are with Nathan S. […]

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Risk Management

Risk Management:  Top 25 Tips to Reduce Clinicians’ Stress Levels

Risk Management: Top 25 Tips to Reduce Clinicians’ Stress Levels

by Donna Vanderpool, MBA, JD Ms. Vanderpool is the Director of Risk Management at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2022;19(10–12):58–59. This ongoing column is […]

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Risk Management: On the Record: Documentation of Psychiatric Treatment

Risk Management: On the Record: Documentation of Psychiatric Treatment

by Ann L. McNary, JD Ms. McNary is Senior Risk Manager at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2022;19(7–9):77–79. This ongoing column is dedicated to providing information […]

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Risk Management: Adjusting to Your New Normal

Risk Management: Adjusting to Your New Normal

by Ann L. McNary, JD Ms. McNary is Senior Risk Manager at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2022;19(4–6):87–89. This ongoing column is dedicated to […]

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Trial Methodology

CNS Summit 2022 Abstracts of Poster Presentations

CNS Summit 2022 Abstracts of Poster Presentations

A message from the editor Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased to provide you with this reference guide to some of the innovative research presented during the CNS Summit 2022 event. The supplement is also available online by visiting www.innovationscns.com. […]

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CNS Summit 2021 Abstracts of Poster Presentations

CNS Summit 2021 Abstracts of Poster Presentations

A message from the editor Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased to provide you with this reference guide to some of the innovative research presented during the CNS Summit 2021 event. The supplement is also available online by visiting www.innovationscns.com. […]

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CNS Summit 2020 Abstracts of Poster Presentations

CNS Summit 2020 Abstracts of Poster Presentations

A message from the editor Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased to provide you with this reference guide to some of the innovative research that was presented during the CNS Summit 2020 event. The supplement is also available online by […]

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Recent Posts

Gender-affirming Care for Transgender Patients

Gender-affirming Care for Transgender Patients

| April 1, 2022

by Nita Bhatt MD, MPH; Jesse Cannella, MSIII; and Julie P. Gentile, MD, MBA Dr. Bhatt is Associate Director of Medical Student Education and Associate Professor in the Department of Psychiatry at Wright State University in Dayton, Ohio. Mr. Cannella is a medical student at Wright State University Boonshoft School of Medicine in Dayton, Ohio. […]

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October–December 2022 Digital Edition

October–December 2022 Digital Edition

| December 1, 2022

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Olfactory Dysfunction in Incidental Lewy Body Disease and Parkinson’s Disease:  An Update

Olfactory Dysfunction in Incidental Lewy Body Disease and Parkinson’s Disease: An Update

| December 1, 2022

by Shemonti Hasan, MD; Charles H. Adler, MD, PhD; Nan Zhang, MS; Geidy E. Serrano, PhD; Lucia I. Sue, BS; Holly A. Shill, MD; Shyamal H. Mehta, MD, PhD; Thomas G. Beach, MD, PhD; and Erika D. Driver-Dunckley, MD Drs. Hasan, Adler, Mehta, and Driver-Dunckley are with the Parkinson’s Disease and Movement Disorders Center, Department of Neurology, […]

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Impact of COVID-19 Pandemic on Psychiatric Patients at Clinical Trial Sites

Impact of COVID-19 Pandemic on Psychiatric Patients at Clinical Trial Sites

| December 1, 2022

by Maria Fe Garcia-Rada, MPS, and Robert E. Litman, MD Ms. Garcia-Rada and Dr. Litman are with CenExel CBH Health in Gaithersburg, Maryland. Dr. Litman is with Georgetown University Medical School in Washington, DC.  Funding: Funding was provided by CenExel Clinical Research. Disclosures: Dr. Litman is a member of the Speaker’s Bureau for Janssen, AbbVie, […]

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Stroop Test for Parkinson’s Disease with Deep Brain Stimulation: A Systematic Review

Stroop Test for Parkinson’s Disease with Deep Brain Stimulation: A Systematic Review

| December 1, 2022

by Amer Cavalheiro Hamdan, PhD, and Mariana Drabik Vieira, MSc  Dr. Hamdan is with the Graduate Program in Psychology, Department of Psychology, Federal University of Parana in Curitiba, Brazil. Dr. Vieira is a psychologist, candidate to master’s in psychology, Department of Psychology, Graduate Program in Psychology, Federal University of Parana in Curitiba, Brazil. Funding: No […]

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Play Therapy via Telemedicine in a Child with Sudden-onset Emotional Disorder During the COVID-19 Lockdown Period: A Case Report

Play Therapy via Telemedicine in a Child with Sudden-onset Emotional Disorder During the COVID-19 Lockdown Period: A Case Report

| December 1, 2022

by Swapnajeet Sahoo, MD; Diksha Sachdeva, MPhil; Sana Yumnam, MD; Ruchita Shah, MD; Aseem Mehra, MD; and Sandeep Grover, MD All authors are with the Department of Psychiatry, Post Graduate Institute of Medical Education and Research in Chandigarh, India. Funding: No funding was provided for this study. Disclosures: The authors have no conflicts of interest […]

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Virtual and Augmented Reality-based Treatments for Phantom Limb Pain: A Systematic Review

Virtual and Augmented Reality-based Treatments for Phantom Limb Pain: A Systematic Review

| December 1, 2022

by Andrew Yimu Vassantachart, MD; Elizabeth Yeo, MD; and Brian Chau, MD Dr. Vassantachart is with Loma Linda University School of Medicine in Loma Linda, California. Dr. Yeo is with the Department of Physical Medicine and Rehabilitation, Loma Linda University Health, in Loma Linda, California. Dr. Chau is with the Department of Physical Medicine and […]

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