Innovations in Clinical Neuroscience

Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 18, ISSUE 10–12, OCTOBER-DECEMBER 2021

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Innov Clin Neurosci. 2021;18(10–12):8. Dear Editor: Primary central nervous system (CNS) lymphoma (pCNL) is a rare neoplasia predominantly of the brain. Histologically, most of these neoplasias are diffuse large B-cell lymphomas.1 Although the exact diagnosis requires pathological confirmation, magnetic resonance imaging (MRI) often shows characteristic results, such as enhancement.2 However, nonenhancing pCNL have been described […]

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Ketamine Augmentation of Exposure Response Prevention Therapy for Obsessive-compulsive Disorder

Ketamine Augmentation of Exposure Response Prevention Therapy for Obsessive-compulsive Disorder

by Hugo Bottemanne, MD, and Alice Arnould, MSc Dr. Bottemanne and Ms. Arnould are with Sorbonne University, Paris Brain Institute–Institut du Cerveau (ICM), and Department of Psychiatry (Pitié-Salpêtrière Hospital, APHP) in Paris, France. FUNDING: No funding was provided for this study.  DISCLOSURES: The author has no conflicts of interest relevant to the content of this […]

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Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease:  A Case Report

Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report

by Stefania Brotini, MD Dr. Brotini is with the Movement Disorder Center, Department of Neurology, San Giuseppe Hospital in Empoli, Florence, Italy FUNDING: No funding was provided for this study.  DISCLOSURES: The author has no conflicts of interest relevant to the content of this article.  Innov Clin Neurosci. 2021;18(10–12):12–14. ABSTRACT: Background. Camptocormia is a complication in […]

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PAST ARTICLES

Letter to the Editor: Beyond Robotics and Virtual Reality: It’s Time to go Back to the Patient!

Letter to the Editor: Beyond Robotics and Virtual Reality: It’s Time to go Back to the Patient!

Dear Editor: There is great scientific activity regarding robotics, virtual reality (VR), telehealth, and digital medicine.1–2 A “mischievous” point of view could tell that they are running after the real life, like the poor boy’s finger in the Harlem Dam hole. Evidence-based medicine, cost/efficacy ratio, and consensus papers are trying to put the hat over […]

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Letter to the Editor: Beware of Neuroleptic Malignant Syndrome in COVID-19 Pandemic

Letter to the Editor: Beware of Neuroleptic Malignant Syndrome in COVID-19 Pandemic

Dear Editor: I read with great interest the recent article by Buttar et al1 detailing fatal consequences of the chronic neuroleptic malignant syndrome (NMS) from the United States. The authors prescribed the challenges of treating psychiatric patients with the possibility of NMS. They also indicated that ethnic groups concerning metabolic enzyme polymorphisms for antipsychotics, such […]

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Letter to the Editor: Adjunct Ketamine in Electroconvulsive Therapy

Letter to the Editor: Adjunct Ketamine in Electroconvulsive Therapy

Dear Editor: Electroconvulsive therapy (ECT) is a medical treatment that involves the electrical stimulation of the brain under general anesthesia. This treatment modality has been utilized worldwide for over 80 years.1 According to the American Psychiatric Association, ECT is indicated for major depression, mania, and schizophrenia.2 Unfortunately, there are occasions in which a psychiatrist is […]

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PSYCHOTHERAPY ROUNDS

Bringing It in the Room: Addressing the Impact of Racism on the Therapeutic Alliance

Bringing It in the Room: Addressing the Impact of Racism on the Therapeutic Alliance

by Anjuli S. Maharaj, DO, PGY-3 in Psychiatry; Nita V. Bhatt, MD, MPH; and Julie P. Gentile, MD Dr Maharaj is with Wright State University Boonshoft School of Medicine in Fairborn, Ohio. Dr. Bhatt is the Associate Director of Medical Student Education in Psychiatry at Wright State University Boonshoft School of Medicine in Fairborn, Ohio. […]

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Providing Culturally Competent Mental Health Care for Muslim Women

Providing Culturally Competent Mental Health Care for Muslim Women

by Zainab Saherwala, DO; Sabina Bashir, BA; and Danielle Gainer, MD Drs. Saherwala and Gainer and Student Doctor Bashir are with Wright State University in Fairborn, Ohio. FUNDING: No funding was provided for this study. DISCLOSURES: The author has no conflicts of interest relevant to the content of this article. ABSTRACT: Providing culturally competent care […]

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A Flash of Hope: Eye Movement Desensitization and Reprocessing

A Flash of Hope: Eye Movement Desensitization and Reprocessing

by Danielle Gainer, MD; Sarah Alam, BS; Harris Alam; and Hannah Redding, BA Dr. Gainer, Sarah Alam, and Ms. Redding are with Wright State University Boonshoft School of Medicine in Fairborn, Ohio. Harris Alam is with University of Central Florida in Orlando, Florida. FUNDING: No funding was provided. DISCLOSURES: The authors have no conflicts of […]

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Schizophrenia

Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

by JP Lindenmayer, MD; Beverly J. Insel, PhD; Anzalee Khan, PhD; McKenzie Osborne, BA; Abraham Goldring, MA; and Mary Seddo, BA Drs. Lindenmayer, Insel, and Khan, Ms. Osborne and Seddo, and Mr. Goldring are with Manhattan Psychiatric Center in New York City, New York. Drs. Lindenmayer and Khan and Mr. Goldring are with Nathan S. […]

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Anatomical Association Between Schizophrenia and Cerebellum

Anatomical Association Between Schizophrenia and Cerebellum

by Rajashekar Reddy Yeruva, MD; Yafei Shang, MD; Ben Schoenbachler, MD; Sharon Nuss, MS; and Rif S El-Mallakh, MD Dr. Yeruva is with Baylor Scott and White Medical Center in Round Rock, Texas. Drs. Shang, Schoenbachler, El-Mallakh, and Sharon Nuss are with the University of Louisville School of Medicine in Louisville, Kentucky. FUNDING: No funding […]

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Capturing Clinical Symptoms with Ecological Momentary Assessment: Convergence of Momentary Reports of Psychotic and Mood Symptoms with Diagnoses and Standard Clinical Assessments

Capturing Clinical Symptoms with Ecological Momentary Assessment: Convergence of Momentary Reports of Psychotic and Mood Symptoms with Diagnoses and Standard Clinical Assessments

by Philip D. Harvey, PhD; Michelle L. Miller, MS; Raeanne C. Moore, PhD; Colin A. Depp, PhD; Emma  M. Parrish, BS; and Amy E. Pinkham, PhD Dr. Harvey is with the University of Miami Miller School of Medicine in Miami, Florida, and Research Service at Bruce W. Carter VA Medical Center in Miami, Florida. Ms. […]

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Risk Management

Risk Management: Fact or Fiction

Risk Management: Fact or Fiction

by Donna Vanderpool, MBA, JD Ms. Vanderpool is Director of Risk Management at Professional Risk Management Services (PRMS) FUNDING: No funding was provided for the preparation of this article. DISCLOSURES: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2021;18(10–12):38–39. Questions 1. A clinician’s former […]

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Risk Management: The Standard of Care

Risk Management: The Standard of Care

by Donna Vanderpool, MBA, JD Ms. Vanderpool  is Director of Risk Management at Professional Risk Management Services (PRMS) FUNDING: No funding was provided for the preparation of this article. DISCLOSURES: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. This ongoing column is dedicated to providing information to […]

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Maintenance and Destruction of Treatment Records

Maintenance and Destruction of Treatment Records

by  Ann L. McNary, JD Ms. McNary is a Senior Risk Manager at PRMS, Inc. FUNDING: No funding was provided for the preparation of this article. DISCLOSURES: The author is an employee of PRMS Inc., a risk-management consulting company for health care providers. This ongoing column is dedicated to providing information to our readers on […]

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Cognition

Development of a Cognitive Ability Assessment Tool for a Pediatric School-aged Population

Development of a Cognitive Ability Assessment Tool for a Pediatric School-aged Population

by Franco Di Cesare, MD; Leonardo Di Cesare; and Cristiana Di Carlo, MSc  Dr. F. Di Cesare, Mr. L. Di Cesare, and Ms. Di Carlo are with Leoben Research srl in Rome, Italy. FUNDING: This study was supported by Leoben Research.  DISCLOSURES: The authors are employed by Leoben Research.  Innov Clin Neurosci. 2021;18(10–12):30–37. ABSTRACT: Objective. […]

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Frontiers in Detecting Consciousness: The Growing Use of EEG Analysis

Frontiers in Detecting Consciousness: The Growing Use of EEG Analysis

Dear Editors: There is growing scientific interest regarding the use of electroencephalogram (EEG) and multivariate analysis as a means to classify states of consciousness. A recent work assessed the validity of 28 potential EEG markers of consciousness, using the Disorders of Consciousness (DoC)-Forest (the name of the algorithm) tool, to establish states of awareness in […]

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Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer’s Disease Stage

Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer’s Disease Stage

by Yue Deng, MSc; Brianna M. Marsh, BSc student; and Jackob Moskovitz, PhD Mr. Deng, Ms. Marsh, and Dr. Moskovitz are with the Department of Pharmacology and Toxicology at the School of Pharmacy, University of Kansas in Lawrence, Kansas. Funding: Support for the studies were provided by the KU ADC P30 AG035982 and the Landon […]

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Recent Posts

October–December 2021 Digital Edition

October–December 2021 Digital Edition

| October 1, 2021

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Clinician- and Patient-reported Endpoints in CNS Orphan Drug Clinical Trials: ISCTM Position Paper on Best Practices for Endpoint Selection, Validation, Training, and Standardization

Clinician- and Patient-reported Endpoints in CNS Orphan Drug Clinical Trials: ISCTM Position Paper on Best Practices for Endpoint Selection, Validation, Training, and Standardization

| October 1, 2021

by Joan Busner, PhD; Gahan Pandina, PhD; Silvia Zaragoza domingo PhD; Anna-Karin Berger PhD; Maria T. Acosta, MD; Nahome Fisseha, PharmD; Joseph Horrigan, MD; Jelena Ivkovic, MD; William Jacobson, PhD; Dennis Revicki, PhD; and Victoria Villalta-Gil, PhD, MSc All authors are members of the ISCTM Working Group for Rare Disease/Orphan Drug Development; Drs. Busner and Pandina […]

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Is Neuromuscular Electrical Stimulation Effective in Treating Severe Dysarthria: Insights from a Case Study

Is Neuromuscular Electrical Stimulation Effective in Treating Severe Dysarthria: Insights from a Case Study

| October 1, 2021

by Matteo Berenati, MSc; Antonino Naro, MD, PhD; Cinzia Calabrò, MSc; Michele Torrisi, PsyD; Salvatore Massimiliano Cardali, MD; and Rocco Salvatore Calabrò, MD, PhD Mr. Berenati, Ms. C. Calabrò, and Drs. Naro, Torrisi, and R. Calabrò are with IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Dr. Cardali is with UOC Neurochirurgia, AOU Policlinico G Martino in […]

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