Innovations in Clinical Neuroscience

Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 19, ISSUE 1–3, JANUARY-MARCH 2022

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

by Muhannad M. Alsharidah, MBBS; Mohammad Uzair, BS; Sarah S. Alseneidi, MBBS; Afnan A. Alkharan, MBBS; Reem Fahd Bunyan, MBBS; and Shahid Bashir, PhD Drs. Alsharidah and Alseneidi are with the College of Medicine, King Saud University in Riyadh, Saudi Arabia. Mr. Uzair is with the Department of Biological Sciences, Faculty of Basic and Applied […]

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Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single  Case Pilot Study on a Novel Neuromodulation Approach

Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation Approach

by Antonino Naro, MD, PhD; Luana Billeri, MSc; Paola Lauria, MSc; Alfredo Manuli, MSc; and Rocco Salvatore Calabrò, MD  Drs. Naro and Calabrò, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS Centro Neurolesi Bonino Pulejo–Piemonte in Messina, Italy. Funding: No funding was provided for this study.   Disclosures: The authors have no conflicts […]

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Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

by Loredana Raciti, MD, PhD; Francesca Antonia Arcadi, MD, PhD; and Rocco Salvatore Calabrò, MD, PhD Drs. Raciti, Arcadi, and Calabrò are with IRCCS Centro Neurolesi “Bonino Pulejo” in Messina, Italy. Funding: No funding was provided for this study.   Disclosures: The authors have no conflicts of interest relevant to the content of this article.  Innov […]

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PAST ARTICLES

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Innov Clin Neurosci. 2021;18(10–12):8. Dear Editor: Primary central nervous system (CNS) lymphoma (pCNL) is a rare neoplasia predominantly of the brain. Histologically, most of these neoplasias are diffuse large B-cell lymphomas.1 Although the exact diagnosis requires pathological confirmation, magnetic resonance imaging (MRI) often shows characteristic results, such as enhancement.2 However, nonenhancing pCNL have been described […]

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Ketamine Augmentation of Exposure Response Prevention Therapy for Obsessive-compulsive Disorder

Ketamine Augmentation of Exposure Response Prevention Therapy for Obsessive-compulsive Disorder

by Hugo Bottemanne, MD, and Alice Arnould, MSc Dr. Bottemanne and Ms. Arnould are with Sorbonne University, Paris Brain Institute–Institut du Cerveau (ICM), and Department of Psychiatry (Pitié-Salpêtrière Hospital, APHP) in Paris, France. FUNDING: No funding was provided for this study.  DISCLOSURES: The author has no conflicts of interest relevant to the content of this […]

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Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease:  A Case Report

Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report

by Stefania Brotini, MD Dr. Brotini is with the Movement Disorder Center, Department of Neurology, San Giuseppe Hospital in Empoli, Florence, Italy FUNDING: No funding was provided for this study.  DISCLOSURES: The author has no conflicts of interest relevant to the content of this article.  Innov Clin Neurosci. 2021;18(10–12):12–14. ABSTRACT: Background. Camptocormia is a complication in […]

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PSYCHOTHERAPY ROUNDS

Brief Psychodynamic Psychotherapy: A Review and Illustrative Case Vignette

Brief Psychodynamic Psychotherapy: A Review and Illustrative Case Vignette

by Jessica Porcelan, MD, and Katherine Scribner  Dr. Porcelan is an Assistant Professor with Wright State University Boonshoft School of Medicine in Fairborn, Ohio. Ms. Scribner is a fourth-year medical school student with Wright State University Boonshoft School of Medicine in Fairborn, Ohio. Funding: No funding was provided for this study. Disclosures: The author has […]

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Bringing It in the Room: Addressing the Impact of Racism on the Therapeutic Alliance

Bringing It in the Room: Addressing the Impact of Racism on the Therapeutic Alliance

by Anjuli S. Maharaj, DO, PGY-3 in Psychiatry; Nita V. Bhatt, MD, MPH; and Julie P. Gentile, MD Dr Maharaj is with Wright State University Boonshoft School of Medicine in Fairborn, Ohio. Dr. Bhatt is the Associate Director of Medical Student Education in Psychiatry at Wright State University Boonshoft School of Medicine in Fairborn, Ohio. […]

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Providing Culturally Competent Mental Health Care for Muslim Women

Providing Culturally Competent Mental Health Care for Muslim Women

by Zainab Saherwala, DO; Sabina Bashir, BA; and Danielle Gainer, MD Drs. Saherwala and Gainer and Student Doctor Bashir are with Wright State University in Fairborn, Ohio. FUNDING: No funding was provided for this study. DISCLOSURES: The author has no conflicts of interest relevant to the content of this article. ABSTRACT: Providing culturally competent care […]

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Schizophrenia

Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

Effects of Clozapine on Neurocognitive Functions in Schizophrenia: A Naturalistic Comparison to Non-clozapine Antipsychotics

by JP Lindenmayer, MD; Beverly J. Insel, PhD; Anzalee Khan, PhD; McKenzie Osborne, BA; Abraham Goldring, MA; and Mary Seddo, BA Drs. Lindenmayer, Insel, and Khan, Ms. Osborne and Seddo, and Mr. Goldring are with Manhattan Psychiatric Center in New York City, New York. Drs. Lindenmayer and Khan and Mr. Goldring are with Nathan S. […]

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Anatomical Association Between Schizophrenia and Cerebellum

Anatomical Association Between Schizophrenia and Cerebellum

by Rajashekar Reddy Yeruva, MD; Yafei Shang, MD; Ben Schoenbachler, MD; Sharon Nuss, MS; and Rif S El-Mallakh, MD Dr. Yeruva is with Baylor Scott and White Medical Center in Round Rock, Texas. Drs. Shang, Schoenbachler, El-Mallakh, and Sharon Nuss are with the University of Louisville School of Medicine in Louisville, Kentucky. FUNDING: No funding […]

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Capturing Clinical Symptoms with Ecological Momentary Assessment: Convergence of Momentary Reports of Psychotic and Mood Symptoms with Diagnoses and Standard Clinical Assessments

Capturing Clinical Symptoms with Ecological Momentary Assessment: Convergence of Momentary Reports of Psychotic and Mood Symptoms with Diagnoses and Standard Clinical Assessments

by Philip D. Harvey, PhD; Michelle L. Miller, MS; Raeanne C. Moore, PhD; Colin A. Depp, PhD; Emma  M. Parrish, BS; and Amy E. Pinkham, PhD Dr. Harvey is with the University of Miami Miller School of Medicine in Miami, Florida, and Research Service at Bruce W. Carter VA Medical Center in Miami, Florida. Ms. […]

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Risk Management

Risk Management: Responding to Record Requests: The Basics

Risk Management: Responding to Record Requests: The Basics

by Ann L. McNary, JD Ms. McNary is Senior Risk Manager at Professional Risk Management Services (PRMS) Funding: No funding was provided for the preparation of this article. Disclosures: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2022;19(1–3):71–73. This ongoing column is dedicated to […]

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Risk Management: Fact or Fiction

Risk Management: Fact or Fiction

by Donna Vanderpool, MBA, JD Ms. Vanderpool is Director of Risk Management at Professional Risk Management Services (PRMS) FUNDING: No funding was provided for the preparation of this article. DISCLOSURES: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. Innov Clin Neurosci. 2021;18(10–12):38–39. Questions 1. A clinician’s former […]

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Risk Management: The Standard of Care

Risk Management: The Standard of Care

by Donna Vanderpool, MBA, JD Ms. Vanderpool  is Director of Risk Management at Professional Risk Management Services (PRMS) FUNDING: No funding was provided for the preparation of this article. DISCLOSURES: The author is an employee of PRMS. PRMS manages a professional liability insurance program for psychiatrists. This ongoing column is dedicated to providing information to […]

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Cognition

Development of a Cognitive Ability Assessment Tool for a Pediatric School-aged Population

Development of a Cognitive Ability Assessment Tool for a Pediatric School-aged Population

by Franco Di Cesare, MD; Leonardo Di Cesare; and Cristiana Di Carlo, MSc  Dr. F. Di Cesare, Mr. L. Di Cesare, and Ms. Di Carlo are with Leoben Research srl in Rome, Italy. FUNDING: This study was supported by Leoben Research.  DISCLOSURES: The authors are employed by Leoben Research.  Innov Clin Neurosci. 2021;18(10–12):30–37. ABSTRACT: Objective. […]

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Frontiers in Detecting Consciousness: The Growing Use of EEG Analysis

Frontiers in Detecting Consciousness: The Growing Use of EEG Analysis

Dear Editors: There is growing scientific interest regarding the use of electroencephalogram (EEG) and multivariate analysis as a means to classify states of consciousness. A recent work assessed the validity of 28 potential EEG markers of consciousness, using the Disorders of Consciousness (DoC)-Forest (the name of the algorithm) tool, to establish states of awareness in […]

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Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer’s Disease Stage

Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer’s Disease Stage

by Yue Deng, MSc; Brianna M. Marsh, BSc student; and Jackob Moskovitz, PhD Mr. Deng, Ms. Marsh, and Dr. Moskovitz are with the Department of Pharmacology and Toxicology at the School of Pharmacy, University of Kansas in Lawrence, Kansas. Funding: Support for the studies were provided by the KU ADC P30 AG035982 and the Landon […]

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Recent Posts

January–March 2022 Digital Edition

January–March 2022 Digital Edition

| January 1, 2022

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Making Sense of the Matrix: A Qualitative Assessment and Commentary on Connecting Psychiatric Symptom Scale Items to the Research Domain Criteria (RDoC)

Making Sense of the Matrix: A Qualitative Assessment and Commentary on Connecting Psychiatric Symptom Scale Items to the Research Domain Criteria (RDoC)

| January 1, 2022

by Leslie Citrome, MD, MPH; Anissa Abi-Dargham, MD; Robert M. Bilder, PhD; Ruth A. Duffy, PhD; Boadie W. Dunlop, MD; Philip D. Harvey, PhD; Diego A. Pizzagalli, PhD; Carol A. Tamminga, MD; Roger S. McIntyre, MD; and John M. Kane, MD Dr. Citrome is with New York Medical College in Valhalla, New York. Dr. Abi-Dargham is with […]

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Selective Serotonin Reuptake Inhibitors (SSRIs) and Their Effect on Patient Aggression in Adult Patients in a State Psychiatric Facility: A Retrospective Analysis

Selective Serotonin Reuptake Inhibitors (SSRIs) and Their Effect on Patient Aggression in Adult Patients in a State Psychiatric Facility: A Retrospective Analysis

| January 1, 2022

by Carolyn O’Donnell, PharmD; Tammie Lee Demler, PharmD, MBA, BCGP, BCPP; and Eileen Trigoboff, RN, PMHCNS-BC, DNS, DABFN;  Drs. O’Donnell, Demler, and Trigoboff are with the State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York. Drs. O’Donnell and Demler are with the New York State […]

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