Dr. Bert Vargas speaks with Dr. Christian Moher about the growing importance of brain health and the evolving understanding of Alzheimer’s disease across the disease continuum. Dr. Moher discusses how advances in identifying Alzheimer’s disease–related changes years before symptom onset have shifted his approach toward more proactive conversations about cognitive health with his patients. He also highlights the role of primary care clinicians have in recognizing cognitive decline, initiating screening, and following patients longitudinally as concerns develop. The conversation emphasizes the need for continued awareness of brain health.