Dear Colleagues:

Welcome to the March issue of Innovations in Clinical Neuroscience. Innovation in neuroscience may not always be demonstrated in the creation of a novel drug or technologically advanced device. Innovation can be found in using what you know works and does not work and artfully crafting it into a treatment plan that addresses the unique needs of a patient.

This month, we bring you a collection of brief articles that covers a wide range of topics within neuroscience, from data analysis of antipsychotic medication use to risk reduction through the use of REMS in practice. We hope these articles help keep you informed of the latest research and thus help you treat your patients with successful outcomes. Included in this mix, however, are three articles that focus on single patient cases. Two of the case reports (“Refractory Delirium Tremens: A Case Report and Brief Review” by Mattoo et al and “Suprathreshold Duloxetine for Treatment-Resistant Depression, Anorexia Nervosa Binge-Purging type, and Obsessive-Compulsive Disorder: A Case Report” by Safer and Arnow) are excellent examples of clinicians using the information available to them to artfully craft successful treatment plans to address their patients’ individual needs. The third case, however, is a unique interpretation of the clinical picture of the 19th century Anglo-Indian prince known as Dyce Sombre and his alleged “madness.” In “The Mysterious Illness of Dyce Sombre” Pies et al exemplify the importance of taking the whole patient into consideration before formulating a treatment plan, rather than merely addressing specific symptoms.

We wrap the issue up with some of our regular columns we think you are sure to find of interest. In this month’s The Interface, Sansone and Sansone examine characteristics of borderline personality disorder in the primary care setting in their article, “Borderline Personality and Externalized Aggression.” And in Meymandi at Large, Dr. Meymandi shares his opinion on gambling in, “The Despotic Habit of Gambling.”

We hope you enjoy the issue. As always, please feel free to contact us with your comments.

Amir Kalali, MD
Editor, Innovations in Clinical Neuroscience