Innovations in Clinical Neuroscience

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Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 13, ISSUE 11–12, NOVEMBER–DECEMBER 2016

Current e-Edition

Current e-Edition

CLICK HERE TO ACCESS E-EDITION   PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Editors Message and Issue Highlights: November–December 2016

Editors Message and Issue Highlights: November–December 2016

Dear Colleagues: Welcome to the November–December 2016 issue of Innovations in Clinical Neuroscience. We begin this issue with a thoughtful review and commentary by Calabró et al titled, “The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?” Here the authors review current opinions and ethical issues concerning end-of-life […]

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The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?

The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?

by Rocco Salvatore Calabrò, MD, PhD; Antonino Naro, MD, PhD; Rosaria De Luca, MS, PhD; Margherita Russo, MD, PhD; Lory Caccamo, PhD; Alfredo Manuli, MS; Alessia Bramanti; and Placido Bramanti, MD Drs. Calabró, Naro, de Luca, Russo, Manuli, A. Bramanti, and P. Bramanti are from the IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy; and Dr. […]

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Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report

Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report

by Swapnajeet Sahoo, MD; Aseem Mehra, MD; and Sandeep Grover, MD All from the Department of Psychiatry at the Postgraduate Institute of Medical Education and Research in Chandigarh, India Innov Clin Neurosci. 2016;13(11–12):25–27 Funding: No funding was received for the preparation of this article. Financial disclosures: The authors have no conflicts of interest relevant to […]

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Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia

Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia

by Takahiko Nagamine, MD, PhD Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi, Japan. Innov Clin Neurosci. 2016;13(11–12):28–31 Funding: No funding was received for the preparation of this article. Financial disclosures: The author has no conflicts of interest relevant to the content of this article. Key words: Cardiac arrest, hypothermia, risperidone, J-wave Abstract: […]

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Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation

Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation

by Sangsoo Lee, MD, MSc; Chang Jin Oh, MD; and Jeong Won Seong, MD Dr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is with the Department of Pain Medicine and Anesthesiology at the Seoul Samsung Union Clinic in South Korea; and Dr. Seong is with the Department of […]

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PAST ARTICLES (user login required)

Editor’s Message: September–October 2016 Issue Highlights

Editor’s Message: September–October 2016 Issue Highlights

Dear Colleagues: Welcome to the September-October 2016 issue of Innovations in Clinical Neuroscience (ICNS). As the official journal of the CNS Summit, the International Society for CNS Drug Development (ISCDD), and the International Society for CNS Clinical Trials and Methodology (ISCTM), an important part of our editorial mission is to accelerate and enhance the development […]

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Performance, Reliability, Usability, and Safety of the ID-Cap System for Ingestion Event Monitoring in Healthy Volunteers:  A Pilot Study

Performance, Reliability, Usability, and Safety of the ID-Cap System for Ingestion Event Monitoring in Healthy Volunteers: A Pilot Study

by Glen P. Flores, PhD; Brian Peace, BS; Tony C. Carnes, PhD; Susan L. Baumgartner, PharmD, MBA; D. Eric Buffkin, Jr., MBA; Neil R. Euliano, PhD; and Larry N. Smith, MD, FACS Drs. Flores, Carnes, Euliano, Mr. Peace, and Mr. Buffkin are with etectRx, Inc. in Newberry, Florida; and Drs. Baumgartner and Smith are from […]

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The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder

by Anthony L. Vaccarino, PhD; Kenneth R. Evans, PhD; Amir H. Kalali, MD; Sidney H. Kennedy, MD, FRCPC; Nina Engelhardt, PhD; Benico N. Frey, MD, MSc, PhD; John H. Greist, MD; Kenneth A. Kobak, PhD; Raymond W. Lam, MD, FRCPC; Glenda MacQueen, MD, PhD, FRCPC; Roumen Milev, MD, PhD, FRCPC, FRCPsych; Franca M. Placenza, PhD; Arun […]

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Assessment of Cognitive and Neurologic Recovery in Ischemic Stroke Drug Trials: Results from a Randomized, Double-blind, Placebo-controlled Study

Assessment of Cognitive and Neurologic Recovery in Ischemic Stroke Drug Trials: Results from a Randomized, Double-blind, Placebo-controlled Study

by Franco Di Cesare, MD; Jessica Mancuso, PhD; Brian Silver, MD; and Peter T. Loudon, PhD Dr. Di Cesare is with Leoben Research Limited in Glasgow, UK; Dr. Mancuso is with Research Statistics at Pfizer in Groton, Connecticut, USA; Dr. Silver is with Rhode Island Hospital and Alpert Medical School of Brown University in Providence, Rhode […]

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Eszopiclone-induced Parasomnia with Suicide Attempt: A Case Report

Eszopiclone-induced Parasomnia with Suicide Attempt: A Case Report

by J. Gibson Pennington, MD, and Jeffrey Guina, MD From Wright-Patterson Air Force Base and Wright State University Boonshoft School of Medicine Department of Psychiatry, Dayton, Ohio Innov Clin Neurosci. 2016;13(9–10):44–48

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Cariprazine for Schizophrenia and Bipolar Disorder

Cariprazine for Schizophrenia and Bipolar Disorder

by Jonathan R. Scarff, MD Dr. Scarff is a staff psychiatrist at the Veterans Affairs Outpatient Clinic in Spartanburg, South Carolina, USA Innov Clin Neurosci. 2016;13(9–10):49–52

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THE NEUROSCIENCE REPORT

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information.   This […]

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The Neuroscience Report—Volume 45 (September 15, 2016): Schizophrenia

The Neuroscience Report—Volume 45 (September 15, 2016): Schizophrenia

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 44 (July 19, 2016): What’s Hot in Neuroimaging?

The Neuroscience Report—Volume 44 (July 19, 2016): What’s Hot in Neuroimaging?

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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SPECIAL ISSUES AND SUPPLEMENTS

Current e-Edition

Current e-Edition

CLICK HERE TO ACCESS E-EDITION   PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Hot Topics in Pain Management

Hot Topics in Pain Management

CLICK HERE TO ACCESS E-EDITION Past Issues                   PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at […]

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Hot Topics in Drug Development

Hot Topics in Drug Development

Hot Topics in Drug Development PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Current Trends in Epilepsy Management

Current Trends in Epilepsy Management

CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Supplement to Nov-Dec 2015 Issue: Abstracts of  Poster Presentations: CNS Summit 2015

Supplement to Nov-Dec 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015

October 7–11, 2015 Boca Raton, Florida Innov Clin Neurosci. 2015;12(11–12 Suppl C):3–17 CNS Drug Compounds Synthesis of carnitine analogues for inhibition of carnitine palmitoyltransferase Presenters: Bornstein J, Garneau-Tsodikova S Affiliations: University of Michigan Life Sciences Institute Background: Type 2 diabetes (T2DM) carries a markedly elevated risk of cerebrovascular disease. Carnitine plays a key role transporting […]

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Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of  Poster Presentations

Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of Poster Presentations

Innov Clin Neurosci. 2015;12(5–6 Suppl B):3–19 Click here to access the e-Edition, a digital replica of the printed version. CNS Drug Compounds/Therapies/Devices Long-acting injectable antipsychotics (LAIs) in outpatient treatment of DMS-IV-R schizophrenia Presenters: Bellnier T, Patil K, Ortega T, Seeger G Affiliations: SUNY University at Buffalo, GPI Clinical Research Background: The treatment of schizophrenia with […]

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Other Recent Posts

Current e-Edition

Current e-Edition

| December 1, 2016 | 0 Comments

CLICK HERE TO ACCESS E-EDITION   PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

Continue Reading

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

| December 6, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

Continue Reading

Editors Message and Issue Highlights: November–December 2016

Editors Message and Issue Highlights: November–December 2016

| December 1, 2016 | 0 Comments

Dear Colleagues: Welcome to the November–December 2016 issue of Innovations in Clinical Neuroscience. We begin this issue with a thoughtful review and commentary by Calabró et al titled, “The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?” Here the authors review current opinions and ethical issues concerning end-of-life […]

Continue Reading

The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?

The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?

| December 1, 2016 | 0 Comments

by Rocco Salvatore Calabrò, MD, PhD; Antonino Naro, MD, PhD; Rosaria De Luca, MS, PhD; Margherita Russo, MD, PhD; Lory Caccamo, PhD; Alfredo Manuli, MS; Alessia Bramanti; and Placido Bramanti, MD Drs. Calabró, Naro, de Luca, Russo, Manuli, A. Bramanti, and P. Bramanti are from the IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy; and Dr. […]

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Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report

Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report

| December 1, 2016 | 0 Comments

by Swapnajeet Sahoo, MD; Aseem Mehra, MD; and Sandeep Grover, MD All from the Department of Psychiatry at the Postgraduate Institute of Medical Education and Research in Chandigarh, India Innov Clin Neurosci. 2016;13(11–12):25–27 Funding: No funding was received for the preparation of this article. Financial disclosures: The authors have no conflicts of interest relevant to […]

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Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia

Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia

| December 1, 2016 | 0 Comments

by Takahiko Nagamine, MD, PhD Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi, Japan. Innov Clin Neurosci. 2016;13(11–12):28–31 Funding: No funding was received for the preparation of this article. Financial disclosures: The author has no conflicts of interest relevant to the content of this article. Key words: Cardiac arrest, hypothermia, risperidone, J-wave Abstract: […]

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Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation

Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation

| December 1, 2016 | 0 Comments

by Sangsoo Lee, MD, MSc; Chang Jin Oh, MD; and Jeong Won Seong, MD Dr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is with the Department of Pain Medicine and Anesthesiology at the Seoul Samsung Union Clinic in South Korea; and Dr. Seong is with the Department of […]

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Ransomware: Minimizing the Risks

Ransomware: Minimizing the Risks

| December 1, 2016 | 0 Comments

by Justin Pope, JD Mr. Pope is Associate Risk Manager at PRMS, Inc. in Arlington, Virginia. Innov Clin Neurosci. 2016;13(11–12)37–40 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager […]

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Differential Diagnoses: Encephalopathy or Psychosis?

Differential Diagnoses: Encephalopathy or Psychosis?

| December 1, 2016 | 0 Comments

by Malathi Latha Perugula, MD, and Steven Lippmann, MD The authors are from the Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, Kentucky. Innov Clin Neurosci. 2016;13(11–12):41–42 This column series compares neurological conditions that pose differential challenges in diagnoses. Funding: No funding was provided for the preparation of this article. […]

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The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

| November 11, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information.   This […]

Continue Reading