Innovations in Clinical Neuroscience

Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 15, ISSUE 3–4, MARCH–APRIL 2018

Editorial Message and Issue Highlights–Vol. 15, No. 3–4, March-April 2018

Editorial Message and Issue Highlights–Vol. 15, No. 3–4, March-April 2018

Dear Colleagues: Welcome to the March–April 2018 issue of Innovations in Clinical Neuroscience (ICNS). We are excited to lead this edition of ICNS with an exciting commentary by Dr. Michael Ehlers, Head of Research and Development at Biogen (Cambridge, Massachusetts). In his article, “Neuroscience is the Next Oncology,” Dr. Ehlers explores  “the signs of a […]

Continue Reading

Neuroscience is the Next Oncology

Neuroscience is the Next Oncology

by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a […]

Continue Reading

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury

by Amne Borghol, PharmD, BCPS, BCGP; Michael Aucoin, PharmD; Ifeanyichukwu Onor, PharmD, BCPS; Dana Jamero, PharmD, BCOP; and Fadi Hawawini, DO, CMD  Drs. Borghol, Onor, and Jamero are with the College of Pharmacy at Xavier University of Louisiana in New Orleans, Louisiana. Dr. Aucoin is with the Woman’s Hospital in Baton Rouge, Louisiana. Dr. Hawawini […]

Continue Reading

Effects of Statins and Cholesterol on Patient Aggression: Is There a Connection?

Effects of Statins and Cholesterol on Patient Aggression: Is There a Connection?

by Emily Leppien, PharmD, BCPS; Kimberly Mulcahy, PharmD, BCPS, BCPP; Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP; Eileen Trigoboff, RN, PMHCNS-BC, DNS, DABFN; and Lewis Opler, MD, PhD Drs. Leppien, Mulcahy, Demler, and Trigoboff are with Buffalo Psychiatric Center, New York State Office of Mental Health, and State University of New York, University at Buffalo […]

Continue Reading

Comorbid Insomnia and Psychiatric Disorders: An Update

Comorbid Insomnia and Psychiatric Disorders: An Update

by Khurshid A. Khurshid, MD, FAASM Dr. Khurshid is Clinical Associate Profressor and Chief of the Neuromodulation and Sleep Disorders Program in the Department of Psychiatry at the University of Florida College of Medicine in Gainsville, Florida. Innov Clin Neurosci. 2018;15(3–4):28–32 Funding: No funding was received for the preparation of this article. Disclosures: The author […]

Continue Reading

Psychosis in a Child with Atypical Autism: A Case Report and a Brief Review of the Association of Psychosis and Autism

Psychosis in a Child with Atypical Autism: A Case Report and a Brief Review of the Association of Psychosis and Autism

by Swapnajeet Sahoo, MD; Susanta Kumar Padhy, MD; Neha Singla, MD; and Aakanksha Singh, MD Drs. Sahoo, Singla, and Singh are Senior Residents and Dr. Padhy is Associate Professor in the Department of Psychiatry at the Post Graduate Institute of Medical Education and Research in Chandigarh, India.  Innov Clin Neurosci. 2018;15(3–4):33–36 Funding: The authors have […]

Continue Reading

PAST ARTICLES (user login required)

Editorial Message and Issue Highlights–Vol. 15, No. 1–2, January-February 2018

Editorial Message and Issue Highlights–Vol. 15, No. 1–2, January-February 2018

Continue Reading

Pimavanserin: A Novel Drug Approved to Treat Parkinson’s Disease Psychosis

Pimavanserin: A Novel Drug Approved to Treat Parkinson’s Disease Psychosis

by Amanda K. Kitten, PharmD; Sarah A. Hallowell, PharmD; Stephen Saklad, PharmD, BCPP; and Kirk E. Evoy, PharmD, BCACP, BC-ADM, CTTS Drs. Kitten, Hallowell, Saklad, and Evoy are with the College of Pharmacy, The University of Texas at Austin in Austin, Texas. Innov Clin Neurosci. 2017;15(1–2):16–22

Continue Reading

Effectiveness of Electroconvulsive Therapy (ECT) in Parkinsonian Symptoms: A Case Series

Effectiveness of Electroconvulsive Therapy (ECT) in Parkinsonian Symptoms: A Case Series

by Sandeep Grover, MD; Aditya Somani, MD; Neeru Sahni, MD; Sahil Mehta, DM; Swati Choudhary, MBBS; Rahul Kumar Chakravarty, MBBS; and Anju Moni Rabha, MBBS Drs. Grover, Somani, Sahni, Mehta, Choudhary, Chakravarty, and Rabha are with the Post Graduate Institute of Medical Education and Research, Chadigarh in Chandigarh, India. Innov Clin Neurosci. 2017;15(1–2):23–27

Continue Reading

Lower-extremity Dynamometry as a Novel Outcome Measure  in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy

by Jessica Robinson-Papp, MD, MS; Mary Catherine George, MM, PhD; Alexandra Nmashie, MD; Donald Weisz, PhD; and David M. Simpson, MD Drs. Robinson-Papp, George, Nmashie and Simpson are with the Department of Neurology and Dr. Weisz is with the Department of Neurosurgery—all from the Icahn School of Medicine at Mount Sinai in New York, New […]

Continue Reading

The Benefit of Mirtazapine in the Treatment of Progressive Multifocal Leukoencephalopathy in a Young HIV-positive Patient: A Case Report

The Benefit of Mirtazapine in the Treatment of Progressive Multifocal Leukoencephalopathy in a Young HIV-positive Patient: A Case Report

by Carola Mullins, MD; Jorge Miranda, MS; Hugo Sandoval, PhD; Luis Ramos-Duran, MD; and Silvina B. Tonarelli, MD Drs. Mullins , Sandoval, and Ramos-Duran are with the Department of Radiology, Dr. Miranda is with the Paul Foster School of Medicine, and Dr. Tonarelli is with the Department of Psychiatry— all with Texas Tech University Health […]

Continue Reading

Cognitive Impairment Associated with Cancer: A Brief Review

Cognitive Impairment Associated with Cancer: A Brief Review

by J. Cara Pendergrass, PhD; Steven D. Targum, MD; and John E. Harrison, BSc (hons), PhD, Cpsychol, CSCI Drs. Pendergrass and Targum are with Bracket Global and Clintara LLC, A Bracket Company, in Boston, Massachusetts. Dr. Harrison is with the Alzheimer’s Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center in Amsterdam, […]

Continue Reading

THE NEUROSCIENCE REPORT

Vol. 51 (December 28, 2017): New Discoveries in Neurodegenerative Diseases

Vol. 51 (December 28, 2017): New Discoveries in Neurodegenerative Diseases

Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Discoveries in Neurodegenerative Diseases 5 Journal Articles Pathogenesis and […]

Continue Reading

Vol. 50 (December 20, 2017): Advances in Neuroscience

Vol. 50 (December 20, 2017): Advances in Neuroscience

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Advances […]

Continue Reading

Vol. 49 (December 11, 2017): Neurological Disorders

Vol. 49 (December 11, 2017): Neurological Disorders

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Neurological […]

Continue Reading

Vol. 48 (November 30, 2017): Multiple Sclerosis

Vol. 48 (November 30, 2017): Multiple Sclerosis

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Multiple […]

Continue Reading

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

The Neuroscience Report—Volume 47 (December 6, 2016): Psychology of Technology in Society

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

Continue Reading

The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

The Neuroscience Report—Volume 46 (November 11, 2016): Accessibility of Mental Healthcare

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information.   This […]

Continue Reading

SPECIAL ISSUES AND SUPPLEMENTS

Hot Topics in Multiple Sclerosis

Hot Topics in Multiple Sclerosis

Click the cover below to access the digital editions of Hot Topics in Multiple Sclerosis! March 2018 December 2017 November 2017

Continue Reading

CNS Summit 2017 Abstracts of Poster Presentations

CNS Summit 2017 Abstracts of Poster Presentations

Innov Clin Neurosci. 2017;14(11–12)S1—S20

Continue Reading

Hot Topics in Pain Management

Hot Topics in Pain Management

Click the cover below to access the digital editions of Hot Topics in Pain Management! October 2017 September 2017 August 2017 July 2017

Continue Reading

CNS Summit 2016 Abstracts of Poster Presentations

CNS Summit 2016 Abstracts of Poster Presentations

Innov Clin Neurosci. 2017;14(1–2)3–23 A MESSAGE FROM THE EDITOR Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased to provide you with this reference guide to some of the innovative research that was presented during CNS Summit 2016, which was held October 27 […]

Continue Reading

Supplement to November–December 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015

Supplement to November–December 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015

October 7–11, 2015 Boca Raton, Florida Innov Clin Neurosci. 2015;12(11–12 Suppl C):3–17 CNS Drug Compounds Synthesis of carnitine analogues for inhibition of carnitine palmitoyltransferase Presenters: Bornstein J, Garneau-Tsodikova S Affiliations: University of Michigan Life Sciences Institute Background: Type 2 diabetes (T2DM) carries a markedly elevated risk of cerebrovascular disease. Carnitine plays a key role transporting […]

Continue Reading

Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of Poster Presentations

Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of Poster Presentations

Innov Clin Neurosci. 2015;12(5–6 Suppl B):3–19 CNS Drug Compounds/Therapies/Devices Long-acting injectable antipsychotics (LAIs) in outpatient treatment of DMS-IV-R schizophrenia Presenters: Bellnier T, Patil K, Ortega T, Seeger G Affiliations: SUNY University at Buffalo, GPI Clinical Research Background: The treatment of schizophrenia with LAIs is a significant focus of drug development. The cost of re-hospitalization due […]

Continue Reading

Recent Posts

Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder

Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder

| April 1, 2018 | 0 Comments

by Steven D. Targum, MD; Christopher Murphy, PhD; Jibran Khan, BA; Laura Zumpano, BA; Mark Whitlock, PhD; Arthur A. Simen, MD, PhD; and Brendon Binneman, MD†  Drs. Targum and Murphy are with Bracket Global LLC in Boston, Massachusetts. Dr. Khan was with Bracket Global LLC in Boston, Massachusetts, at the time of this study. Ms. […]

Continue Reading

Hot Topics in Neuroscience: Is Electroconvulsive Therapy a Treatment for Depression Following Traumatic Brain Injury?

Hot Topics in Neuroscience: Is Electroconvulsive Therapy a Treatment for Depression Following Traumatic Brain Injury?

| April 1, 2018 | 0 Comments

This ongoing column explores off-label or emerging treatment options, drug development trends, and theoretical concepts in the field of neuroscience. by Anja Srienc, PhD, MD; Puneet Narang, MD; Simrat Sarai, MD; Yee Xiong, MD; and Steven Lippmann, MD Dr. Srienc is with the Medical Scientist Training Program & Graduate Program in Neuroscience at the University […]

Continue Reading

Risk Management: Prescribing Controlled Substances: Managing  the Risks

Risk Management: Prescribing Controlled Substances: Managing the Risks

| April 1, 2018 | 0 Comments

by Donna Vanderpool, MBA, JD Ms. Vanderpool is Vice President, Risk Management at PRMS, Inc. in Arlington, Virginia. Innov Clin Neurosci. 2018;15(3–4):47–51 Funding: No funding was provided for the preparation of this article. Disclosures: The authors have no conflicts of interest relevant to the content of this article. Abstract: This ongoing column is dedicated to providing […]

Continue Reading

Letter to the Editor: Discussing ANT1 role in Amyotrophic Lateral Sclerosis pathogenesis

Letter to the Editor: Discussing ANT1 role in Amyotrophic Lateral Sclerosis pathogenesis

| April 1, 2018 | 0 Comments

Innov Clin Neurosci. 2018;15(3–4):11–14 Dear Editor: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a rapid progression, affecting motor neurons in the brain and spinal cord, ultimately leading to respiratory failure and death.1 ALS might present as sporadic (sALS) or familial (fALS), both of which are clinically indistinguishable.1 ALS etiology is still unknown, despite […]

Continue Reading