Innovations in Clinical Neuroscience

Providing evidence-based information in a practical, easy-to-read format for practicing clinicians, investigators, industry scientists, and other entities involved in the field of neuroscience

VOLUME 13, ISSUE 3–4, MARCH–APRIL 2016

Editor’s Message and Issue Highlights

Editor’s Message and Issue Highlights

Dear Colleagues: Welcome to the March–April 2016 issue of Innovations in Clinical Neuroscience (ICNS). Attitudes regarding marijuana use have changed dramatically over the past 50-plus years in the United States. According to data from the Pew Research Center, support for the legalization of marijuana has gone from 12 percent of the American population in favor […]

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Why Not Pot? A Review of the Brain-based Risks of Cannabis

Why Not Pot? A Review of the Brain-based Risks of Cannabis

by Kai MacDonald, MD, and Katherine Pappas, BA Dr. MacDonald and Ms. Pappas are with UC San Diego Psychiatry, San Diego, CA, USA Innov Clin Neurosci. 2016;13(3–4):13–22 Funding: Dr. MacDonald’s work is sponsored in part by the Goodenough Neuroscience Research Fund. Financial disclosures: The authors have no conflicts of interest relevant to the content of […]

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Medical Marijuana for Epilepsy?

Medical Marijuana for Epilepsy?

by Murali K. Kolikonda, MD; Kavitha Srinivasan, MD; Manasa Enja, MD; Vishwanath Sagi, MD; and Steven Lippmann, MD Drs. Kolikonda and Sagi are from the Department of Neurology, Dr. Srinivasan is from the Clinical Translational Research Support Unit, and Drs. Enja and Lippmann are from the Department of Psychiatry, University of Louisville School of Medicine, […]

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Inter-rater Reliability Assessment of ASPECT-R (A Study Pragmatic-Explanatory Characterization Tool-Rating)

Inter-rater Reliability Assessment of ASPECT-R (A Study Pragmatic-Explanatory Characterization Tool-Rating)

by Cynthia A. Bossie, PhD; Larry D. Alphs, MD, PhD; David Williamson, PhD; Lian Mao, PhD; Clennon Kurut, BS; and the ASPECT-R Rater Team Drs. Bossie, Alphs, and Williamson are with Janssen Scientific Affairs, LLC, Titusville, New Jersey, USA; Dr. Mao and Mr. Kurut are with Janssen Research & Development, Titusville, New Jersey, USA Innov […]

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A Case of Transient  Global Amnesia:  A Review and How It May Shed Further Insight into the Neurobiology of Delusions

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions

by David R. Spiegel, MD; Aidan L. McCroskey, MD; and Branden A. Deyerle, MD All with the Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia. Innov Clin Neurosci. 2016;13(3–4):32–41 Funding: No funding was received for the preparation of this manuscript. Financial disclosures: The authors have no conflicts of interest relevant to […]

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Managing the Suicidal Patient in a Split-treatment Relationship

Managing the Suicidal Patient in a Split-treatment Relationship

by Ann McNary, JD Ms. McNary is a Senior Risk Manager with PRMS, Inc., Arlington, Virginia Innov Clin Neurosci. 2016;13(3–4):42–45 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager […]

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Editor’s Message and Issue Highlights, January–February 2016

Editor’s Message and Issue Highlights, January–February 2016

Dear Colleagues: Welcome to the January–February 2016 issue of Innovations in Clinical Neuroscience. We start this issue with the article “Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study,” by Calabró et al. Here, the investigators evaluated the prevalence and causes of erectile dysfunction in a group of hospital inpatients suffering from neurologic […]

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ASPECT-R—A Tool to Rate the Pragmatic and Explanatory Characteristics of a Clinical Trial Design

ASPECT-R—A Tool to Rate the Pragmatic and Explanatory Characteristics of a Clinical Trial Design

by Larry D. Alphs, MD, PhD, and Cynthia A. Bossie, PhD Drs. Alphs and Bossie are with Janssen Scientific Affairs, LLC, Titusville, New Jersey, USA. Innov Clin Neurosci. 2016;13(1–2):15–26 Funding: Financial support provided by Janssen Scientific Affairs, LLC. Financial Disclosures: Drs. Alphs and Bossie are full-time employees of Janssen Scientific Affairs, LLC. Key Words: ASPECT-R, […]

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Current Trends in Epilepsy Management

Current Trends in Epilepsy Management

CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Editor’s Message and Issue Highlights: November–December 2015

Editor’s Message and Issue Highlights: November–December 2015

Dear Colleagues: Welcome to the November–December 2015 issue of Innovations in Clinical Neuroscience. First, I would like to call your attention to the accompanying supplement to this issue of the journal, a compendium of abstracts from the 2015 CNS Summit poster presentations. Each year, the CNS Summit brings together drug development leaders from pharma, research […]

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Supplement to Nov-Dec 2015 Issue: Abstracts of  Poster Presentations: CNS Summit 2015

Supplement to Nov-Dec 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015

October 7–11, 2015 Boca Raton, Florida Innov Clin Neurosci. 2015;12(11–12 Suppl C):3–17 CNS Drug Compounds Synthesis of carnitine analogues for inhibition of carnitine palmitoyltransferase Presenters: Bornstein J, Garneau-Tsodikova S Affiliations: University of Michigan Life Sciences Institute Background: Type 2 diabetes (T2DM) carries a markedly elevated risk of cerebrovascular disease. Carnitine plays a key role transporting […]

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Editor’s Message and Issue Highlights, September–October 2015

Editor’s Message and Issue Highlights, September–October 2015

Dear Colleagues: Welcome to the September–October 2015 issue of Innovations in Clinical Neuroscience. We start this issue with an intriguing review by Yarlagadda et al titled,“Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain.” Here the authors explore a possible link between in-utero exposure to a high […]

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THE NEUROSCIENCE REPORT

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 41 (May 20, 2016): Human Brain vs. Artificial Intelligence

The Neuroscience Report—Volume 41 (May 20, 2016): Human Brain vs. Artificial Intelligence

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 40 (May 6, 2016): Anti-addiction Medications

The Neuroscience Report—Volume 40 (May 6, 2016): Anti-addiction Medications

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 39 (April 11, 2016): Rapid-acting Antidepressants

The Neuroscience Report—Volume 39 (April 11, 2016): Rapid-acting Antidepressants

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 38 (March 22, 2016): Building Better Clinical Trials

The Neuroscience Report—Volume 38 (March 22, 2016): Building Better Clinical Trials

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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SPECIAL ISSUES AND SUPPLEMENTS

Hot Topics in Drug Development

Hot Topics in Drug Development

Hot Topics in Drug Development PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Hot Topics in Pain Management

Hot Topics in Pain Management

CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Current Trends in Epilepsy Management

Current Trends in Epilepsy Management

CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Supplement to Nov-Dec 2015 Issue: Abstracts of  Poster Presentations: CNS Summit 2015

Supplement to Nov-Dec 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015

October 7–11, 2015 Boca Raton, Florida Innov Clin Neurosci. 2015;12(11–12 Suppl C):3–17 CNS Drug Compounds Synthesis of carnitine analogues for inhibition of carnitine palmitoyltransferase Presenters: Bornstein J, Garneau-Tsodikova S Affiliations: University of Michigan Life Sciences Institute Background: Type 2 diabetes (T2DM) carries a markedly elevated risk of cerebrovascular disease. Carnitine plays a key role transporting […]

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Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of  Poster Presentations

Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of Poster Presentations

Innov Clin Neurosci. 2015;12(5–6 Suppl B):3–19 Click here to access the e-Edition, a digital replica of the printed version. CNS Drug Compounds/Therapies/Devices Long-acting injectable antipsychotics (LAIs) in outpatient treatment of DMS-IV-R schizophrenia Presenters: Bellnier T, Patil K, Ortega T, Seeger G Affiliations: SUNY University at Buffalo, GPI Clinical Research Background: The treatment of schizophrenia with […]

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Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium

Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium

by Jared W. Young, PhD; William Z. Potter, MD, PhD; Steve Riley, PharmD, PhD; Geert J. Groeneveld, MD, PhD; Bruce J. Kinon, MD; Mike F. Egan, MD; and Douglas E. Feltner, MD Dr. Young is with the Department of Psychiatry, University of California San Diego, La Jolla, California, and Research Service, VA San Diego Healthcare […]

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Other Recent Posts

Current e-Edition

Current e-Edition

| April 1, 2016 | 0 Comments

CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

Continue Reading

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience

| June 24, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics

| June 13, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 41 (May 20, 2016): Human Brain vs. Artificial Intelligence

The Neuroscience Report—Volume 41 (May 20, 2016): Human Brain vs. Artificial Intelligence

| May 20, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

Continue Reading

The Neuroscience Report—Volume 40 (May 6, 2016): Anti-addiction Medications

The Neuroscience Report—Volume 40 (May 6, 2016): Anti-addiction Medications

| May 6, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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The Neuroscience Report—Volume 39 (April 11, 2016): Rapid-acting Antidepressants

The Neuroscience Report—Volume 39 (April 11, 2016): Rapid-acting Antidepressants

| April 11, 2016 | 0 Comments

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s […]

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Hot Topics in Drug Development

Hot Topics in Drug Development

| April 3, 2016 | 0 Comments

Hot Topics in Drug Development PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.

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Editor’s Message and Issue Highlights

Editor’s Message and Issue Highlights

| April 1, 2016 | 0 Comments

Dear Colleagues: Welcome to the March–April 2016 issue of Innovations in Clinical Neuroscience (ICNS). Attitudes regarding marijuana use have changed dramatically over the past 50-plus years in the United States. According to data from the Pew Research Center, support for the legalization of marijuana has gone from 12 percent of the American population in favor […]

Continue Reading

Why Not Pot? A Review of the Brain-based Risks of Cannabis

Why Not Pot? A Review of the Brain-based Risks of Cannabis

| April 1, 2016 | 0 Comments

by Kai MacDonald, MD, and Katherine Pappas, BA Dr. MacDonald and Ms. Pappas are with UC San Diego Psychiatry, San Diego, CA, USA Innov Clin Neurosci. 2016;13(3–4):13–22 Funding: Dr. MacDonald’s work is sponsored in part by the Goodenough Neuroscience Research Fund. Financial disclosures: The authors have no conflicts of interest relevant to the content of […]

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Medical Marijuana for Epilepsy?

Medical Marijuana for Epilepsy?

| April 1, 2016 | 0 Comments

by Murali K. Kolikonda, MD; Kavitha Srinivasan, MD; Manasa Enja, MD; Vishwanath Sagi, MD; and Steven Lippmann, MD Drs. Kolikonda and Sagi are from the Department of Neurology, Dr. Srinivasan is from the Clinical Translational Research Support Unit, and Drs. Enja and Lippmann are from the Department of Psychiatry, University of Louisville School of Medicine, […]

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Inter-rater Reliability Assessment of ASPECT-R (A Study Pragmatic-Explanatory Characterization Tool-Rating)

Inter-rater Reliability Assessment of ASPECT-R (A Study Pragmatic-Explanatory Characterization Tool-Rating)

| April 1, 2016 | 0 Comments

by Cynthia A. Bossie, PhD; Larry D. Alphs, MD, PhD; David Williamson, PhD; Lian Mao, PhD; Clennon Kurut, BS; and the ASPECT-R Rater Team Drs. Bossie, Alphs, and Williamson are with Janssen Scientific Affairs, LLC, Titusville, New Jersey, USA; Dr. Mao and Mr. Kurut are with Janssen Research & Development, Titusville, New Jersey, USA Innov […]

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