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Category: Neurology

Outcome of Ischemic Stroke at Six Months with Neuroglobin as a Marker

by Yetty Ramli, MD, SpN(K); Fadhlan Rusdi, MD, SpN; Mohammad Kurniawan, MD, SpN(K); Mohamad Sadikin, MD, DSc; and Florencia Evelyn, MD Drs. Ramli, Rusdi, Kurniawan, and Evelyn are with the

Analysis of Levels of Vitamin D, Beta-Amyloid 42, Indoxyl Sulfate, and Serum Parathyroid Hormone in Hemodialysis Patients with Cognitive Impairment

by Prof. Yuliarni Syafrita, Sp.N(K); Harnavi Harun, Sp.PD-KGH, FINASIM; Restu Susanti, Sp.S(K) M. Biomed; and Syarif Indra, Sp.N(K) Prof. Syafrita and Drs. Susanti Indra are with the Department of Neurology,

The Impact of High-density Lipoprotein Cholesterol (HDL-C) Levels and Risk of Movement Disorders in Patients Taking Antipsychotics

by CAROLYN O’DONNELL, PharmD; TAMMIE LEE DEMLER, BS, PharmD, MBA, BCGP, BCPP; EILEEN TRIGOBOFF, RN, PMHCNS-BC, DNS, DABFN; and CLAUDIA LEE, MD Dr. O’Donnell is with Edward Hines Jr. Veterans

Artificial Intelligence and Neurorehabilitation: Fact vs. Fiction

by Nicola Fiorente, MD; Sepehr Mojdehdehbaher, BSc; and Rocco Salvatore Calabrò, MD, PhD Dr. Fiorente is with Polimedica Fisio and Sport in Cittadella (PD), Italy. Dr. Mojdehdehbaher is with Engineering

Back to the Future: An Appraisal of the Role of Osteopathic Manipulative Treatment in Patients with Neurological Diseases

by Mirjam Bonanno, MSc, and Rocco Salvatore Calabrò, MD, PhD Ms. Bonanno and Dr. Calabrò are with Neurorehabilitation Unit, IRCCS Neurolesi Center “Bonino-Pulejo” in Messina, Italy. Funding: No funding was

Exploring the Complex Relationship Between Antiepileptic Drugs and Suicidality: A Systematic Literature Review

by Aksha M. Memon, MBBS, MD, MPH; Jigar Katwala, MBBS, MD; Clarice Douille, BS; Caitlin Kelley, BS; and Varun Monga, MD Dr. Memon is with Creighton University School of Medicine

Music in Parkinson’s Disease Rehabilitation: Are We Heading in the Right Direction?

by Nicola Fiorente, MD, and Rocco Salvatore Calabrò, MD, PhD Dr. Fiorente is with Polimedica Fisio & Sport in Cittadella (PD), Italy. Dr. Calabrò is with IRCCS Centro Neurolesi “Bonino-Pulejo”

Remote Cognitive Therapeutic Exercise in Facial Nerve Palsy Rehabilitation: Pandemic Tips and Tricks

by Filippo Cavallaro, PT; Simona Portaro, MD, PhD; Teresa Pintaudi, PT; Mariachiara Ceccio, PT; and Angelo Alito, MD All authors are with the University of Messina in Messina, Italy. Funding:

Letter to the Editor: Antipsychotics and Parkinson’s Disease: A Troubling Mix

Funding/financial disclosures. The authors have no conflict of interest relevant to the content of this letter. Our studies are supported by the following grants: Fundação de Amparo à Pesquisa do

Olfactory Dysfunction in Incidental Lewy Body Disease and Parkinson’s Disease: An Update

by Shemonti Hasan, MD; Charles H. Adler, MD, PhD; Nan Zhang, MS; Geidy E. Serrano, PhD; Lucia I. Sue, BS; Holly A. Shill, MD; Shyamal H. Mehta, MD, PhD; Thomas

Stroop Test for Parkinson’s Disease with Deep Brain Stimulation: A Systematic Review

by Amer Cavalheiro Hamdan, PhD, and Mariana Drabik Vieira, MSc Dr. Hamdan is with the Graduate Program in Psychology, Department of Psychology, Federal University of Parana in Curitiba, Brazil. Dr.

Letter to the Editor: Steroid Management in a Patient with Myasthenia Gravis Undergoing COVID-19 Vaccination

Funding/financial disclosures. The authors have no conflict of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(7–9):8.

Post-stroke Sexual Dysfunction in Men: Epidemiology, Diagnostic Work-up, and Treatment

by Rocco Salvatore Calabrò, MD, PhD Dr. Calabrò is with IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Funding: No funding was provided for this article. Disclosures: The author has no

Abnormality of Contingent Negative Variation Correlates with Parkinson’s Disease Severity

by Plamen Tzvetanov, MD, Phd, DSc, FRCP; Ivan Lisichkov, MD, PhD; Rossen T. Rousseff MD, PhD; Vishwajit Hegde, MD, FRCP; and Sergey Kostadinov, MD, PhD Prof. Tzvetanov is with the

Acute Thalamic Ischemic Stroke in an Older Patient Newly Vaccinated with COVID-19 Vaccine Based on Adenoviral Vectors

by Kelly Mesa-Gamarra, MD; Mario Pineda-Paternina, MD; Edgar Castillo, MD; Loida Camargo, MD, MSc; Alexander Pabón, MD; Jorge Herrera-Pino, MD, PhD; Nicole Caldichoury, MSc; Pascual A. Gargiulo, MD, PhD; Yuliana

Comparative Analysis of Treatment Outcomes in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab, Azathioprine, and Mycophenolate Mofetil: A Systematic Review and Meta-analysis

by Christy Magdalena, MD, MRes; Audrey Clarissa, MD, MRes; and Nathania Sutandi, MD, MRes All authors are with Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital in Jakarta,

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

by Muhannad M. Alsharidah, MBBS; Mohammad Uzair, BS; Sarah S. Alseneidi, MBBS; Afnan A. Alkharan, MBBS; Reem Fahd Bunyan, MBBS; and Shahid Bashir, PhD Drs. Alsharidah and Alseneidi are with

Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation Approach

by Antonino Naro, MD, PhD; Luana Billeri, MSc; Paola Lauria, MSc; Alfredo Manuli, MSc; and Rocco Salvatore Calabrò, MD Drs. Naro and Calabrò, Ms. Billeri, Ms. Lauria, and Mr. Manuli

Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

by Loredana Raciti, MD, PhD; Francesca Antonia Arcadi, MD, PhD; and Rocco Salvatore Calabrò, MD, PhD Drs. Raciti, Arcadi, and Calabrò are with IRCCS Centro Neurolesi “Bonino Pulejo” in Messina,

Pimavanserin in the Treatment of Parkinson’s Disease Psychosis: Meta-analysis and Meta-regression of Randomized Clinical Trials

by Zeeshan Mansuri, MD, MPH; Abhishek Reddy, MD; Ramu Vadukapuram, MD; Chintan Trivedi, MD, MPH; and Amy Amara, MD, PhD Dr. Mansuri is with the Department of Psychiatry, Boston Children’s

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Innov Clin Neurosci. 2021;18(10–12):8. Dear Editor: Primary central nervous system (CNS) lymphoma (pCNL) is a rare neoplasia predominantly of the brain. Histologically, most of these neoplasias are diffuse large B-cell

Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report

by Stefania Brotini, MD Dr. Brotini is with the Movement Disorder Center, Department of Neurology, San Giuseppe Hospital in Empoli, Florence, Italy FUNDING: No funding was provided for this study.

Is Neuromuscular Electrical Stimulation Effective in Treating Severe Dysarthria: Insights from a Case Study

by Matteo Berenati, MSc; Antonino Naro, MD, PhD; Cinzia Calabrò, MSc; Michele Torrisi, PsyD; Salvatore Massimiliano Cardali, MD; and Rocco Salvatore Calabrò, MD, PhD Mr. Berenati, Ms. C. Calabrò, and

Sexual Function and Disability in the Neurorehabilitation Setting: An Urgent Need for a Multidisciplinary Approach

by Rocco Salvatore Calabrò, MD, PhD, and Alfredo Manuli, MSc Dr. Calabrò is with the IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Mr. Manuli is with the Physical Medicine and

Letter to the Editor: Beyond Robotics and Virtual Reality: It’s Time to go Back to the Patient!

Dear Editor: There is great scientific activity regarding robotics, virtual reality (VR), telehealth, and digital medicine.1–2 A “mischievous” point of view could tell that they are running after the real

Letter to the Editor: Beware of Neuroleptic Malignant Syndrome in COVID-19 Pandemic

Dear Editor: I read with great interest the recent article by Buttar et al1 detailing fatal consequences of the chronic neuroleptic malignant syndrome (NMS) from the United States. The authors

Cerebellar Atrophy Associated with Primary Sjögren’s Syndrome: Diagnosis, Therapy, and Virtual Reality Rehabilitation: A Case Report

by Emanuele Lo Voi, PhD; Giorgio Carmelo Basile, MD; Alessia Bramanti, PhD; Giuseppe Paladina, Annalisa Militi, MD; Daniele Bruschetta, MD; Angelo Alito,MD; Filippo Cavallaro; Salvatore Bertino, MD; and Demetrio Milardi,

Pudendal Neuralgia: The Need for a Holistic Approach—Lessons From a Case Report

by Simon Gabriël Beerten, MD, MSc, and Rocco Salvatore Calabrò, MD, PhD Dr. Beerten is with the Department of Public Health and Primary Care at KU Leuven in Leuven, Belgium.

A Rare Case of Fahr’s Syndrome in a Patient with Secondary Hypoparathyroidism and Neuropsychiatric Symptoms

by Eirini Beneki, MD, MSc; Xenofon Papazarkadas, MD, MSc; Achillefs Karras, MD,MSc; Konstantinos Kalantzis, MD, MSc; and Konstantinos Tsatiris, MD, MSc Drs. Beneki and Tsatiris are with the Department of

A Case Report on Robot-aided Gait Training in Primary Lateral Sclerosis Rehabilitation: Rationale, Feasibility and Potential Effectiveness of a Novel Rehabilitation Approach

by Simona Portaro, MD, PhD; Laura Ciatto, PT; Loredana Raciti, MD, PhD; Enrico Aliberti, MSc; Riccardo Aliberti, Msc; Antonino Naro MD, PhD; and Rocco Salvatore Calabrò, MD, PhD All authors

Fetal Alcohol Spectrum Disorder—Issues of Misdiagnosis and Missed Diagnosis in Black Youth: A Case Report

by Gokce Ergun, PhD; Michelle S. Schultz, PsyD; and Eman K. Rettig, PsyD Drs. Ergun and Schultz are with the School of Professional Psychology at Wright State University in Dayton,

Brain Health Executives: A Transdisciplinary Workforce Innovation—A Commentary

by Harris A. Eyre, MBBS (hons.), PhD; Michael Berk, MD, PhD; Erin Smith; Jeffrey Cummings, MD, ScD; and Mark Heinemeyer, MSc Dr. Eyre and Mr. Heinemeyer are co-founders of the

Energy Drink Use in Adolescents With and Without ADHD: Trends and Influences

by Chiranjir Narine, MD; Jennifer Weller, PhD; and Kathleen Mathieson, PhD, CIP Dr. Narine is the Medical Director of Valleywise Behavioral Health/District Medical Group in Phoenix, Arizona. Dr. Weller is

Rat Lung Worm Disease Caused by Angiostrongylus Cantonensis: A Review of Clinical and Diagnostic Characteristics and Lessons from a Severe Case in Hawaii

by Sittichai Khamsai, MD; Kathleen Howe, MSc; Pewpan M. Intapan, MD; Wanchai Maleewong, PhD; Verajit Chotmongkol, MD; and Kittisak Sawanyawisuth, MD, PhD Drs. Khamsai, Chotmongkol, and Sawanyawisuth are with the

Letters to the Editor: What About Biomarkers for Parkinson’s Disease?

Dear Editor: Parkinson’s disease (PD) affects over 600,000 patients in the United States; these numbers might double by 2040, as the population of older people increases.1 Diagnostic clues include the

Longitudinal Data in Patients with Niemann-Pick Type C Disease Under Combined High Intrathecal and Low Intravenous Dose of 2-hydroxylpropyl-β-cyclodextrin

by Evangelia Bountouvi, MD, PhD; Melpomeni Giorgi, MD; Anna Papadopoulou, PhD; Kaj Blennow, PhD; Ingemar Björkhem, PhD; Maria Tsirouda, PhD; Spyridon Kanellakis, Msc, PhD; Andreas Fryganas, MD; Maria Spanou, MD;

Catatonia in a 6-year-old Patient Following Disseminated Group A Streptococcus Infection

by Philip B Cawkwell, MD; Ivan Daniel Mayor, BA; and Richard J. Shaw,MD Drs. Cawkwell and Shaw and Mr. Mayor are with the Department of Psychiatry and Behavioral Sciences, Division

Blood–Brain Barrier: COVID-19, Pandemics, and Cytokine Norms

by Atmaram Yarlagadda, MD; Samuel L. Preston, DO; Rachel P. Jeyadhas, MD; Adam Edward Lang, PharmD; Rasha Hammamieh, PhD; And Anita H. Clayton, MD Dr. Yarlagadda is the Installation Director

Effects of Prismatic Lenses on Lateral Axial Dystonia in Parkinson’s Disease: A Pilot Study

by Michele Meglio, PhD Student; Enrica Olivola, MD, PhD; Marco Santilli, BSC; Francesco Lena, MSC, PhD; Diego Centonze, MD, PhD; Matteo Bologna, MD, PhD; and Nicola Modugno, MD, PhD Dr.

Transcranial Magnetic Stimulation in Treatment of Adolescent Attention Deficit/Hyperactivity Disorder: A Narrative Review of Literature

[protected]by Aksha M. Memon, MD, MPH Dr. Memon is an Assistant Professor with the Department of Foundational Medical Studies at Oakland University William Beaumont School of Medicine in Rochester Hills,

Minor Head Injury Might Cause Treatable Dementia Due to Severe Hyponatremia

by Takahiko Nagamine, MD, PhD Dr. Nagamine is with the Sunlight Brain Research Center in Hofu, Yamaguchi, Japan. FUNDING: No funding was provided for this study. DISCLOSURES: The author has

Letters to the Editor: Nonresponsive myasthenia is suspicious for congenital myasthenic syndrome or myopathy

Dear Editor: We read the excellent article by Diaz-Abad et al1 about a 54-year-old male patient with double seronegative myasthenia gravis. In the article, Diaz et al1 explained the patient

Intellectual Disability in Morocco: A Pilot Study

by Yousra BENMAKHLOUF, PhD; Zeineb ZIAN, PhD; Kaoutar BEN MAKHLOUF; Naima GHAILANI NOUROUTI, PR; Amina BARAKAT, PR; and Mohcine BENNANI MECHITA PR Drs. Benmakhlouf, Zian, Ghailani Nourouti, Barakat, and Bennani

Who Will Pay for Robotic Rehabilitation? The Growing Need for a Cost-effectiveness Analysis

by Rocco Salvatore Calabrò, MD, PhD; Claudia Müller-Eising, Dr. jur.; Maria Letizia Diliberti; Alfredo Manuli, MSc; Francesca Parrinello, MD; Giuseppe Rao, MD; Vincenzo Barone, Dr. jur.; and Tamara Civello Drs.

Pilot Mental Health Survey, Nepal: Lessons Learned for Survey Design and Instrumentation

by Sushma Dahal, MPH; Meghnath Dhimal, PhD; Sagun Ballav Pant, MD; Pawan Sharma, MD; Kedar Marahatta, MD; Nagendra Luitel, MA; Suraj Shakya, PhD; Sweta Labh, BSc Nursing; Saroj Prasad Ojha,

Multiple Cellular Therapies Along with Neurorehabilitation in Spastic Diplegic Cerebral Palsy: A Case Report

by Alok Sharma, MCh; Nandini Gokulchandran, MD; Pooja Kulkarni, MSc; Sandhya Kiran Mullangi, MPT; Khushboo Bhagawanani, BPT; Vishal Ganar, MPhil; Hemangi Sane, MD; and Prerna Badhe, MD Drs. Sharma and

Neuroleptic Malignant Syndrome: Can Be an Unrecognized Chronic Fatal Disease

by Kulwant Buttar, MD; Eileen Trigoboff, RN, DNS; and Jeffery J Grace, MD Dr. Buttar is with the Buffalo Psychiatric Center in Buffalo New York. Dr. Trigoboff is with the

Meralgia Paresthetica Successfully Treated with Palmithoylethanolamide

by Rocco Salvatore Calabrò MD, PhD; Carmela Casella, MD; Alfredo Manuli, MSc; David Militi, MD; and Giuseppe Gervasi, MD, PhD Drs. Calabrò and Manuli are with IRCCS Centro Neurolesi “Bonino

Latency to First Event is Shorter in Psychogenic Non-epileptic Seizures Than in Epileptic Seizures in an Epilepsy Monitoring Unit

by Vishwanath Sagi MBBS, MPH; Jaime Shoup MD; Ravikiran Chilukuri; and M. Steven Evans MD Drs. Sagi and Evans are with the Department of Neurology at the University of Louisville

Frontiers in Detecting Consciousness: The Growing Use of EEG Analysis

Dear Editors: There is growing scientific interest regarding the use of electroencephalogram (EEG) and multivariate analysis as a means to classify states of consciousness. A recent work assessed the validity

Letter to the Editor: Is Dropped Head Syndrome in Sporadic Late-onset Nemaline Myopathy Always Untreatable?

Dear Editor: Dropped head syndrome (DHS) is a rare condition characterized by cervical paraspinal muscles weakness that causes a recognizable deformity with various degrees of “chin on chest” posture.1–3 Though

The Effects of G2013 (α-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy

by Saeed Tahmasebi, PhD; Gholamreza Azizi, PhD; Hosein Miladi, MSc; Elham Shafiei, MD; Ali N. Kamali, PhD; Haleh Hamedifar PhD; Farimah Fayyaz, MD; Seyed Erfan Rasouli, BSc; Mostafa Kalvandi, MD;

Neurological Aspects of Corona Virus Infectious Disease 2019 (COVID-19)

by Nitin Butala Dr. Butala is a Neurologist and Neurophysiologist at Baptist Health in Jacksonville, Florida and an Assistant professor of Neurology at the Lake Erie College of Osteopathic Medicine

CGRP Inhibitors for Migraine

by Diksha Mohanty, MD, and Steven Lippmann, MD Dr. Mohanty is a Neurology Resident Physician, and Dr. Lippmann is a Psychiatry Emeritus Professor at the University of Louisville School of

Lithium Intoxication in the Elderly: A Possible Interaction between Azilsartan, Fluvoxamine, and Lithium

by Takahiko Nagamine, MD, PhD Dr. Nagamine is with the Sunlight Brain Research Center in Yamaguchi, Japan. FUNDING: No funding was provided for this study. DISCLOSURES: The author has no

Immersive Virtual Reality for Pain Relief in Upper Limb Complex Regional Pain Syndrome: A Pilot Study

by Brian Chau, MD; Ivan Phelan, MSc; Phillip Ta, MD; Bradley Chi, BS; Kevin Loyola, BS; Elizabeth Yeo, BS; Justin Dunn, BS; Sarah Humbert, MD; Justin Hata, MD; Ryan Haglund,

Innovative Approaches for Slowing Disease Progression in Parkinson’s Disease: Takeaways from the 14th Annual International Society for Central Nervous System Clinical Trials and Methodology Scientific Meeting

by Monica Javidnia, PhD; Mark Frasier, PhD; Ira Shoulson, MD; Ibrahim Turkoz, PhD; and Kumar Budur, MD, MS Drs. Javidnia and Shoulson are with the Center for Health + Technology

Letter to the Editor: Role of Horse-assisted Therapy in the Rehabilitation Field: Past, Present, and Future Perspectives

Dear Editor: Central and peripheral nervous system lesions might induce paralysis, weakness, and/or loss of dexterity, which are the main target of rehabilitative interventions.1 In fact, a specific training with

A Look at Genetic Linkage between Clozapine-induced Agranulocytosis, Malignant Hyperthermia, Neuroleptic Malignant Syndrome, and Statin-induced Myopathy

by Nitin Pothen, MD; Shveta Kansal, MD; Theodor Rais, MD; Stacy Doumas, MD; and Ramon Solhkhah, MD Dr. Pothen and Dr. Kansal are with Ocean Medical Center, Hackensack Meridian Health

Placental Barrier and Autism Spectrum Disorders: The Roles of Prolactin and Dopamine in the Developing Fetal Brain—Part II

by Atmaram Yarlagadda, MD; Ganesh Acharya, MD, PhD, FRCOG; Jayaprada Kasaraneni, MBBS; Christiane S. Hampe, PhD; and Anita H. Clayton, MD Dr. Yarlagadda is with the Department of Defense and

Correlation Between the Movement Disorder Society’s Unified Parkinson’s Disease Rating Scale and Nonmotor Scales in Patients with Parkinson’s Disease

by Erika D. Driver-Dunckley, MD; Nan Zhang, MS; Holly A. Shill, MD; Shyamal H. Mehta, MD, PhD; Christine M. Belden, PsyD; Edward Y. Zamrini, MD; Kathryn Davis; Thomas G. Beach,

High-dose Clozapine Withdrawal: A Case Report and Timeline of a Single Potential Withdrawal Seizure

by Megan K. Skelly, PharmD, BCPS; Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP; and Claudia Lee, MD Drs. Skelly, Demler, and Lee are with the State University at Buffalo

Treatment of Functional Gait Abnormality in a Rehabilitation Setting: Emphasizing the Physical Interventions for Treating the Whole Child

by Catherine Butz, PhD; Cindy Iske, MS, OTR/L; Natalie Truba, PhD; and Kristen Trott, PhD Drs. Butz, Truba, and Trott are with the Psychology Department, and Ms. Iske is Program

Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer’s Disease Stage

by Yue Deng, MSc; Brianna M. Marsh, BSc student; and Jackob Moskovitz, PhD Mr. Deng, Ms. Marsh, and Dr. Moskovitz are with the Department of Pharmacology and Toxicology at the

Letter to the Editor: The Click-through Rate as a Measure of Dementia Health Promotion on YouTube

Dear Editor: Social media platforms are increasingly used to disseminate health promotion and patient education.1–5 Impressions click-through rate (CTR) is the number of clicks on a health promotion and/or patient

Adult Neurogenesis in Humans: A Review of Basic Concepts, History, Current Research, and Clinical Implications

by Ashutosh Kumar, MD; Vikas Pareek, PhD; Muneeb A. Faiq, PhD; Sanjib K. Ghosh, MD; and Chiman Kumari, MD Drs. Kumar and Ghosh are with the Department of Anatomy at

The Pathophysiology of Marijuana-induced Encephalopathy and Possible Epilepsy after Ingestion in Children: A Case Series

by Alister Carvalho, MBBS, and Tracy Evans-Gilbert, DM, MPH, CTropMed® Drs. Carvalho and Evans-Gilbert are with the Department of Pediatrics at the Cornwall Regional Hospital in Montego Bay, Jamaica. Dr.

Panic Attacks in Hyperaldosteronism

by Tiffany Y. Lin, MD; Rebecca M. Hedrick, MD; and Waguih William IsHak, MD, FAPA Drs. Lin and IsHak are with the David Geffen School of Medicine at University of

Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis

by Laetitia Pouzol, MSc, PharmD; Luca Piali, PhD; Claude CA Bernard, PhD; Marianne M. Martinic, PhD; Beat Steiner, PhD; and Martine Clozel, MD Drs. Pouzol and Clozel were with Actelion

Virtual Reality Neurorehabilitation for Mobility in Spinal Cord Injury: A Structured Review

by Elizabeth Yeo, BS; Brian Chau, MD; Bradley Chi, BS; David E. Ruckle, BS; and Phillip Ta, MD Ms. Yeo, Dr. Chau, Mr. Chi, and Dr. Ta are with the

Brain Imaging in New Onset Psychiatric Presentations

by Evelyne Baroud, MD; Roula Hourani, MD; and Farid Talih, MD Drs. Baroud and Talih are with the Department of Psychiatry, American University of Beirut Medical Center in Beirut, Lebanon.

Hot Topics in Neuroscience: Marijuana for Parkinson’s Disease?

by Diksha Mohanty, MD, and Steven Lippmann, MD Dr. Mohanty is Research Scholar and Dr. Lippmann is Emeritus Professor at the University of Louisville School of Medicine in Louisville, Kentucky.

Letter to the Editor: Rethinking the robotic rehabilitation pathway for people with amyotrophic lateral sclerosis: a need for clinical trials

By Rocco Salvatore Calabrò, MD, PhD; Simona Portaro, MD, PhD; Alfredo Manuli, MSc; Antonino Leo, MSc; Antonino Naro, MD, PhD; and Alessia Bramanti, PhD IRCCS Centro Neurolesi “Bonino Pulejo”, Messina,

Validation of an Equation Model to Predict Intracranial Pressure in Clinical Studies

by Niro Kasahara, MD; Mateus L. Matuoka, MD; Katia S. Santos, MD; Natasha F.S. Cruz, MD; Alvaro R. Martins, MD; and Stanley Nigro, MD Drs. Kasahara, Matuoka, Santos, and Cruz

Letter to the Editor: When “Cure” becomes “Care” in Robotic Neurorehabilitation: The Critical Role of Nurses in a Novel Sicilian Multidisciplinary Approach

By Alfredo Manuli, MSc, and Rocco Salvatore Calabrò, MD, PhD Funding/financial disclosures. The authors have no conflicts of interest relevant to the content of this letter. No funding was received

Does Vitamin D Deficiency Contribute to Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus?

by Hoda A. Hussein, MD; Lamiaa I. Daker, MD; Nermeen A. Fouad, MD; Azza Elamir, MD; and Shereen R. Mohamed, MD Dr. Hussein is with the Internal Medicine Department, Dr.

Letter to the Editor: Looking Beyond the Obvious: Non-motor Parkinsonism

By Shivani Naik, MD; Murali Kolikonda, MD; Shanti Pittampalli, MD; Steven Lippmann, MD Funding/financial disclosures. The authors have no conflicts of interest relevant to the content of this letter. No

Letter to the Editor: Gait Rehabilitation following Neurological Disorders: Are Robotic Devices the Future?

By Rocco Salvatore Calabrò, MD, PhD; Alfredo Manuli, MSc; Antonino Leo, MSc; Margherita Russo, MD, PhD; Antonino Naro, MD, PhD; and Placido Bramanti, MD IRCCS Centro Neurolesi “Bonino-Pulej0,” Messina, Italy

Worsening Choreoathetosis in Huntington’s Disease with Fluoxetine, Lisdexamfetamine, and Melatonin: A Case Report

By Clayton J. Hamilton, PharmD; Tysen K. Timmer, BA; Robert C. Munjal, MD; Fernando Cardozo-Pelaez, PhD; and Ian R. McGrane, PharmD Dr. Hamilton is with the Department of Pharmacy, Veteran’s

Atypical Neuroleptic Malignant Syndrome Precipitated By Clozapine And Quetiapine Overdose: A Diagnostic Challenge

By David Choon Liang Teo, MBBS, MRC Psych (UK), FAMS (Psychiatry); Hon Khuan Wong, MBBS; Sheng Neng Tan, MBBS, MMED (Psychiatry), FAMS (Psychiatry) Drs. Teo, Wong and Tan are with

Letter to the Editor: Can YouTube® Disseminate Dementia Knowledge to Sinagpore Chinese?

By Benjamin K.P. Woo, MD Funding/financial disclosures: The authors have no conflicts of interest relevant to the content of this letter. No funding was received for the preparation of this

Valbenazine and Deutetrabenazine for Tardive Dyskinesia

By Katie T. B. Touma, PharmD, BCPP, BCPS, and Jonathan R. Scarff, MD Dr. Touma is with the William Jennings Bryan Dorn VA Medical Center Community-based Outpatient Clinic in Anderson,

Letter to the Editor: Discussing ANT1 role in Amyotrophic Lateral Sclerosis pathogenesis

Innov Clin Neurosci. 2018;15(3–4):11–14 Dear Editor: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a rapid progression, affecting motor neurons in the brain and spinal cord, ultimately leading to

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy

by Jessica Robinson-Papp, MD, MS; Mary Catherine George, MM, PhD; Alexandra Nmashie, MD; Donald Weisz, PhD; and David M. Simpson, MD Drs. Robinson-Papp, George, Nmashie and Simpson are with the

The Benefit of Mirtazapine in the Treatment of Progressive Multifocal Leukoencephalopathy in a Young HIV-positive Patient: A Case Report

by Carola Mullins, MD; Jorge Miranda, MS; Hugo Sandoval, PhD; Luis Ramos-Duran, MD; and Silvina B. Tonarelli, MD Drs. Mullins , Sandoval, and Ramos-Duran are with the Department of Radiology,

Cognitive Impairment Associated with Cancer: A Brief Review

by J. Cara Pendergrass, PhD; Steven D. Targum, MD; and John E. Harrison, BSc (hons), PhD, Cpsychol, CSCI Drs. Pendergrass and Targum are with Bracket Global and Clintara LLC, A

Wants Talk Psychotherapy but Cannot Talk: EMDR for Post-stroke Depression with Expressive Aphasia

by Jeffrey Guina, MD, and Cathryn Guina, BSN, RN, CNRN Dr. Jeffrey Guina is with the Department of Psychiatry, Wright State University Boonshoft School of Medicine in Dayton, Ohio, and

Letter to the Editor: Pneumocephalus: Is the needle size significant?

Dear Editor: Pneumocephalus was first described in 1866, and the term was coined in 1914.[1] It is also known as a pneumatocele or intracerebral aerocele and may be classified as

Letter to the editor: Marijuana on the brain— a concern

Dear Editor: Marijuana is one of the most common illegal drugs consumed in the United States. Its use is growing in popularity, especially among young people, partly because of increasing

Letter to the editor: Stroke Telerehabilitation in Sicily: a cost-effective approach to reduce disability?

Dear Editor: Various surveillance systems are used to identify stroke and its sequela around the world, yet it is clear that stroke remains one of the top causes of mortality

The Neuroscience Report—Vol. 51 (December 28, 2017): New Discoveries in Neurodegenerative Diseases

Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5

The Neuroscience Report—Vol. 48 (November 30, 2017): Multiple Sclerosis

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

CNS Summit 2017 Abstracts of Poster Presentations

Innov Clin Neurosci. 2017;14(11–12)S1—S20. A Message From the Editor: Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased

Hot Topics in Neuroscience: Zika Microcephaly

This ongoing column explores off-label or emerging treatment options, drug development trends, and theoretical concepts in the field of neuroscience. by Rajashekar Reddy Yeruva, MD; Hema Madhuri Mekala, MD; Priyanga

It’s Time for Combination Therapies in Multiple Sclerosis

by Jagannadha Avasarala, MD, PhD Dr. Avasarala is Associate Professor of Neurology, Division of Neurology, Department of Medicine, University of South Carolina School of Medicine, Greenville Health System, Greenville, South

Human Embryonic Stem Cells in the Treatment of Autism: A Case Series

by Geeta Shroff, MD Dr. Shroff is Director of Nutech Mediworld in New Delhi, India. Innov Clin Neurosci. 2017;14(3–4):12–16. Funding: No funding was received for the preparation of this article.

Redefining Acute Relapses in Multiple Sclerosis: Implications for Phase 3 Clinical Trials and Treatment Algorithms

by Jagannadha Avasarala, MD, PhD Dr. Avasarala is with the Department of Internal Medicine, Division of Neurology, Greenville Health System, Neuroscience Associates, in Greenville, South Carolina. Innov Clin Neurosci. 2017;14(3–4):38–40.

Letter to the editor: Modafinil Augmentation Therapy in Patient with Traumatic Brain Injury

Innov Clin Neurosci. 2017;14(3–4):11 Dear Editor: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality. Annually, more than two million people in the United States will sustain

Outcomes Assessment in Clinical Trials of Alzheimer’s Disease and its Precursors: Readying for Short-term and Long-term Clinical Trial Needs

by Holly Posner, MD, MS; Rosie Curiel, PsyD; Chris Edgar, PhD; Suzanne Hendrix, PhD; Enchi Liu, PhD; David A. Loewenstein, PhD; Glenn Morrison, MSc, PhD; Leslie Shinobu, PhD; Keith Wesnes,

Performance-based and Observational Assessments in Clinical Trials Across the Alzheimer’s Disease Spectrum

by Philip D. Harvey, PhD; Stephanie Cosentino, PhD; Rosie Curiel, PhD; Terry E. Goldberg, PhD; Jeffrey Kaye, MD; David Loewenstein, PhD; Daniel Marson, PhD, JD; David Salmon, PhD; Keith Wesnes,

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report

by Michael M. Messer, MD, and Irina V. Haller, PhD, MS Dr. Messer is with Behavioral Health Department, Essentia Health, Duluth, MN, and Dr. Haller is with Essentia Institute of

Letters to the Editor: Discussing sexual health after traumatic brain injury: an unmet need!

Innov Clin Neurosci. 2017;14(1–2):11–12. Dear Editor: Sexual dysfunction (SD) after traumatic brain injury (TBI) is an often neglected and underreported issue within the medical field.[1,2] A recent interesting work by

CNS Summit 2016 Abstracts of Poster Presentations

Innov Clin Neurosci. 2017;14(1–2)3–23. A MESSAGE FROM THE EDITOR Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased

The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?

by Rocco Salvatore Calabrò, MD, PhD; Antonino Naro, MD, PhD; Rosaria De Luca, MS, PhD; Margherita Russo, MD, PhD; Lory Caccamo, PhD; Alfredo Manuli, MS; Alessia Bramanti; and Placido Bramanti,

Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation

by Sangsoo Lee, MD, MSc; Chang Jin Oh, MD; and Jeong Won Seong, MD Dr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is

Editor’s Message: September–October 2016 Issue Highlights

Dear Colleagues: Welcome to the September-October 2016 issue of Innovations in Clinical Neuroscience (ICNS). As the official journal of the CNS Summit, the International Society for CNS Drug Development (ISCDD),

Assessment of Cognitive and Neurologic Recovery in Ischemic Stroke Drug Trials: Results from a Randomized, Double-blind, Placebo-controlled Study

by Franco Di Cesare, MD; Jessica Mancuso, PhD; Brian Silver, MD; and Peter T. Loudon, PhD Dr. Di Cesare is with Leoben Research Limited in Glasgow, UK; Dr. Mancuso is

Editor’s Message—Issue Highlights, July–August 2016

Dear Colleagues: Welcome to the July–August 2016 issue of Innovations in Clinical Neuroscience. We start this issue with an interesting study by MacEwan et al titled, “Pharmaceutical Innovation in the

The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis

by Nazanin Arjomand Fard, MSci; Gholamreza Azizi, PhD; and Abbas Mirshafiey, PhD Dr. Fard is with Kish International Campus, University of Tehran, Tehran, Iran; Dr. Azizi is with Imam Hassan

Fahr’s Disease or Fahr’s Syndrome?

by Malathi Latha Perugula, MD, and Steven Lippmann, MD The authors are from the Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, Kentucky. Innov Clin

The Neuroscience Report—Vol. 44 (July 19, 2016): What’s Hot in Neuroimaging?

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 42 (June 13, 2016): Neuroethics

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

Editor’s Message and May–June 2016 Issue Highlights

Dear Colleagues: Welcome to the May–June 2016 issue of Innovations in Clinical Neuroscience. I am pleased to start the issue with the first of a series of articles we’ll be

The Neuroscience Report—Vol. 41 (May 20, 2016): Human Brain vs. Artificial Intelligence

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

Editor’s Message and Issue Highlights

Dear Colleagues: Welcome to the March–April 2016 issue of Innovations in Clinical Neuroscience (ICNS). Attitudes regarding marijuana use have changed dramatically over the past 50-plus years in the United States.

Medical Marijuana for Epilepsy?

by Murali K. Kolikonda, MD; Kavitha Srinivasan, MD; Manasa Enja, MD; Vishwanath Sagi, MD; and Steven Lippmann, MD Drs. Kolikonda and Sagi are from the Department of Neurology, Dr. Srinivasan

Letter to the editor: Diagnosing Disorder of Consciousness: The Opening of Pandora’s Box!

Dear Editor: Consciousness is a multifaceted concept that has two major components: awareness of environment of self (i.e., the content of consciousness) and wakefulness (i.e., the level of consciousness). Whereas

Editor’s Message and Issue Highlights, January–February 2016

Dear Colleagues: Welcome to the January–February 2016 issue of Innovations in Clinical Neuroscience. We start this issue with the article “Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study

by Rocco Salvatore Calabrò, MD, PhD; Giuseppe Gervasi, MD, PhD; Antonino Naro, MD, PhD; Rosaria De Luca, PhD; Michelangelo Marullo, MD; and Placido Bramanti, MD Drs. Calabró, Naro, de Luca,

Quetiapine-induced Bradycardia and Hypotension in the Elderly—A Case Report

by Masaru Nakamura, MD, PhD; Megumi Seki, MD; Yosuke Sato, MD; and Takahiko Nagamine, MD, PhD Dr. Nakamura is with the Department of Psychiatric Internal Medicine, Dr. Seki is with

Amyotrophic Lateral Sclerosis with Frontotemporal Dementia in the Presence of C9orf72 Repeat Expansion—A Case Report

by Chaitanya Bonda, MD; Murali K. Kolikonda, MD; Martin E. Brown, MD; and Steven Lippmann, MD Drs. Bonda and Brown are with the Department of Neurology and Drs. Kolikonda and

The Neuroscience Report—Vol. 34 (January 25, 2016): Patient Adherence

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 31 (December 21, 2015): Hottest of the Hot in Neuroscience: 2015

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuoroscience Report—Vol. 30 (December 14, 2015): Memory

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 27 (November 9, 2015): Parkinson’s Disease

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 24 (October 12, 2015): Treatment Paradigm Shifts in CNS

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

Electroconvulsive Therapy Intervention for Parkinson’s Disease

by Puneet Narang, MD; Anna Glowacki, MD; and Steven Lippmann, MD Dr. Narang is Assistant Professor with the University of Minnesota and Staff Physician and Lead ECT Psychiatrist at Regions

The Neuroscience Report—Vol. 22 (September 28, 2015): Epigenetics

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 21 (September 21, 2015): Emerging Trends in Neuroscience

The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 17 (August 24, 2015): Alzheimer’s Disease

Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5

The Neuroscience Report—Vol. 16 (August 17, 2015): Multiple Sclerosis

Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5

Editor’s Message and Issue Highlights—July–August 2015

Dear Colleagues: Welcome to the July–August 2015 issue of Innovations in Clinical Neuroscience. We begin this issue with a review article by Cole et al titled, “Efficacy of Transcranial Magnetic

The Neuroscience Report—Vol. 12 (July 20, 2015): Epilepsy

The latest in neuroscience—sorted and summarized for you

Editor’s Message and Issue Highlights: May-June 2015

Dear Colleagues: Welcome to the May-June issue of Innovations in Clinical Neuroscience. First, I would like to call your attention to the accompanying supplement to this issue of the journal,

Recurrence of Lobar Hemorrhage: A Red Flag for Cerebral Amyloid Angiopathy-related Inflammation?

by Vaibhav Rastogi, MBBS; Lauren L. Donnangelo; Ganesh Asaithambi, MD; Sharatchandra Bidari, MD; Anna Y. Khanna, MD; and Vishnumurthy Shushrutha Hedna, MD Drs. Rastogi, Asaithambi, Khanna, and Hedna and Ms.

Forced Normalization: Epilepsy and Psychosis Interaction

by Muruga A. Loganathan, MD; Manasa Enja, MD; and Steven Lippmann, MD Dr. Loganathan is a resident in the Department of Psychiatry, Allegheny General Hospital, Pittsburgh, Pennsylvania; Dr. Enja is

The Neuroscience Report—Vol. 5 (June 1, 2015): Cognition

The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 4 (May 26, 2015): ADHD

The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

The Neuroscience Report—Vol. 2 (May 11, 2015): Technology in Healthcare

The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to

Supplement to May–June 2015 Issue: CNS Summit 2014 Abstracts of Poster Presentations

Innov Clin Neurosci. 2015;12(5–6 Suppl B):3–19. CNS Drug Compounds/Therapies/Devices Long-acting injectable antipsychotics (LAIs) in outpatient treatment of DMS-IV-R schizophrenia Presenters: Bellnier T, Patil K, Ortega T, Seeger G Affiliations: SUNY

Functional Cortical and Cerebellar Reorganization in a Case of Moyamoya Disease

by Rocco S. Calabrò, MD, PhD; Placido Bramanti, MD; Annalisa Baglieri, PsyD, PhD; Francesco Corallo, PsyD; Rosaria De Luca, MSc, PhD; Simona De Salvo, MSc; Silvia Marino, MD, PhD All

Consensus Recommendations on Rater Training and Certification

by The CNS Summit Rater Training and Certification Committee: Mark D. West; David G. Daniel, MD; Mark Opler, PhD, MPH; Alexandria Wise-Rankovic, PhD; and Amir Kalali, MD Mr. West is

Editor’s Message: Special Edition of ICNS Covers Multiple Aspects of Assessment of Suicidal Ideation and Behavior

Dear Colleagues: Every year, over 800,000 people commit suicide worldwide, with over 40,000 of these deaths occurring annually in the United States. There are many more who attempt it.[1,2] A

Receptor Tyrosine Kinase and Tyrosine Kinase Inhibitors: New Hope for Success in Multiple Sclerosis Therapy

by Abbas Mirshafiey; Ghasem Ghalamfarsa; Babak Asghari; and Gholamreza Azizi Dr. Mirshafiey is from the Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Dr.

May-June 2014 Issue Highlights and Editorial Message

Dear Colleagues: Welcome to the May-June issue of Innovations in Clinical Neuroscience. This month we open with an interesting contribution by Lehrer and Lorenze titled “Anosognosia in Schizophrenia: Hidden in

March-April 2014 Issue Highlights and Editorial Message

Dear Colleagues: Welcome to the March–April issue of Innovations in Clinical Neuroscience. In this issue, we are pleased to introduce a new commentary series on the communication of clinical trial

The Sunshine Act and Transfers of Value: Impact on Non-industry Authorship

by Leslie Citrome MD, MPH Dr. Citrome is Clinical Professor of Psychiatry and Behavioral Sciences at New York Medical College in Valhalla, New York, and is the Editor-in-Chief for the

Editor’s Message and Issue Highlights—January-February 2014

Dear Colleagues: Welcome to the January-February 2014 issue of Innovations in Clinical Neuroscience.

Can Baropodometric Analysis be a Useful Tool in the Early Diagnosis of Atypical Parkinsonism? Preliminary Findings

by Anna Furnari, MD; Rocco Salvatore Calabrò, MD, PhD; Donatella Imbesi, MD, PhD; Francesca La Fauci Belponer, PT; David Militi, PhD; Giuseppe Gervasi, PhD; Concetta Pastura MD, PhD; and Placido

Would You Recognize Fahr’s Disease if You Saw It?

by Dharmendra Goyal, MD; Mashal Khan, MD; Bushra Qureshi, MD; Catherine Mier, MD; and Steven Lippmann, MD All from the University of Louisville School of Medicine, Department of Psychiatry, Louisville,

Issue Highlights, November–December 2013

Dear Colleagues: Welcome to the November-December issue of Innovations in Clinical Neuroscience.

Abstracts of Poster Presentations CNS Summit 2013

November 14–17, 2013 Boca Raton, Florida Innov Clin Neurosci. 2013;10(11–12 Suppl B):1–18

A Case of Reversible Neuropsychiatric Symptoms in HIV due to Toxic Leukoencephalopathy

by Michelle C. Liu, BA; Amir Garakani, MD; Katherine A. Krauskopf, MD, MPH; and Jessica Robinson-Papp, MD Ms. Liu is from the Icahn School of Medicine at Mount Sinai, New

A Probable Case of Peduncular Hallucinosis Secondary to a Cerebral Peduncular Lesion Successfully Treated with an Atypical Antipsychotic

by Farid Ramzi Talih, MD Dr. Talih is Assistant Professor of Psychiatry at the Department of Psychiatry of the American University of Beirut Medical Center, Beirut, Lebanon. Innov Clin Neurosci.

Clinical Implications of the New Diagnostic Guidelines for Dementia

by Edmund Howe, MD, JD Dr. Howe is Professor, Department of Psychiatry, Director, Programs in Medical Ethics, and Senior Scientist, Center for the Study of Traumatic Stress, Uniformed Services University

Letter to the Editor: Valproate-Induced Hyperammonemic Encephalopathy—A Case Report

Vikas Mangewala, MD; Sajjad Sarwar, MD; Ryan Rosenberger; Theodor Rais, MD; and Michele Knox, PhD Drs. Mangewala and Sarwar are Fellows, Child and Adolescent Psychiatry; Mr. Rosenberger is a medical

Defining a Clinically Meaningful Effect for the Design and Interpretation of Randomized Controlled Trials

by Richard S. E. Keefe, PhD; Helena C. Kraemer, PhD; Robert S. Epstein, MD, MS; Ellen Frank, PhD; Ginger Haynes, PhD; Thomas P. Laughren, MD; James McNulty, AbScB; Shelby D.

How Can Registries Contribute to the Development and Evaluation of CNS Therapeutics?

by Joanne B. Severe, MS, and Annette Stemhagen, DrPH, FISPE Ms. Severe is a research consultant in Rockville, Maryland, and Dr. Stemhagen is with United Biosource Corp. in Bethesda, Maryland.

Poverty and Language Development: Roles of Parenting and Stress

by Suzanne C. Perkins, Eric D. Finegood, and James E. Swain Dr. Perkins is from Department of Psychiatry, Faculty of Medicine, University of Michigan, Ann Arbor, Michigan; Mr. Finegood is

Novel Therapeutic Approach by Nicotine in Experimental Model of Multiple Sclerosis

by Fatemeh Naddafi, MSc; Mohsen Reza Haidari, PhD; Gholamreza Azizi, MSc; Reza Sedaghat, PhD; and Abbas Mirshafiey, PhD Ms. Naddafi is from Department of Cellular and Molecular Biology, Kish International

CNS Sites Cooperate to Detect Duplicate Subjects with a Clinical Trial Subject Registry

by Thomas M. Shiovitz, MD; Charles S. Wilcox, PhD, MPA, MBA; Lilit Gevorgyan, BS; and Adnan Shawkat, BA Dr. Shiovitz is from CTSdatabase, LLC, in Beverly Hills, California and California

Letter to the Editor—“Meow Meow” (Mephedrone) and Catatonia

Venkata Kolli, MBBS; Asish Sharma, MD; Mojgan Amani, MD; Durga Bestha, MBBS, Rajeev Chaturvedi, MBBS Dr. Kolli is Resident,Creighton-Nebraska Psychiatry Residency Program, Omaha, Nebraska; Dr. Sharma is Associate Professor, Department

Deep Brain Stimulation: A Novel Strategy for Treating Alzheimer’s Disease

by Constantine G. Lyketsos, MD, MHS; Steven D. Targum, MD; Jo Cara Pendergrass, PhD; and Andres M. Lozano, MD, PhD, FRCSC, FRSC Constantine G. Lyketsos, MD, MHS, is Elizabeth Plank

Editorial Message and Issue Highlights—July–August 2012 Issue

Dear Colleagues: Welcome to the July-August issue of Innovations in Clinical Neuroscience. We hope everyone enjoyed a relaxing summer spent with family and friends. We start this issue of the

OPSOCLONUS MYOCLONUS

  by Jonathan R. Scarff, MD; Bushra Iftikhar, MD; Aniket Tatugade, MD; Jaekyoung Choi, MD; and Steven Lippmann, MD All from University of Louisville School of Medicine, Department of Psychiatry

Anti-N-methyl-D-aspartate Receptor Encephalitis

by Adil Tumbi, MD, MPH; Amin Gilani, MD; Jonathan R. Scarff, MD; Gagandeep Kaur, MD; and Steven Lippmann, MD All from University of Louisville School of Medicine, Psychiatry Department, Louisville,

Reflexes in Psychiatry

by Richard D. Sanders, MD, and Paulette Marie Gillig, MD, PhD Dr. Sanders is Associate Professor, Departments of Psychiatry and Neurology, Boonshoft School of Medicine, Wright State University, and Dayton

Motor Examinations in Psychiatry

by Richard D. Sanders, MD, and Paulette Marie Gillig, MD, PhD Dr. Sanders is Associate Professor, Departments of Psychiatry and Neurology, Boonshoft School of Medicine, Wright State University, and Dayton

Neuroimaging in Delirious Intensive Care Unit Patients: A Preliminary Case Series Report
There exists uncertainty regarding the role of magnetic resonance imaging in the evaluation of intensive care unit delirious patients. This case series describes preliminary magnetic resonance imaging findings obtained because
Psychiatry, Neurology, and the Role of the Cerebellum
The roles of the cerebellum in pain perception, attention deficit disorder, autism, dementia, and schizophrenia are discussed. Practical observations and tests to assess cerebellar function in the psychiatrist’s office are
Curbside Consultations

Psychiatry (Edgemont) 2010;7(5):51–53 Question: Frequently, a colleague will catch me in the hallway at the hospital or at a professional meeting and ask my opinion about a patient he or

Cranial Nerve VIII: Hearing and Vestibular Functions

by Richard D. Sanders, MD, and Paulette Marie Gillig, MD, PhD Dr. Sanders is Associate Professor, Departments of Psychiatry and Neurology, Boonshoft School of Medicine, Wright State University, and Ohio

When Should Brain Imaging be Performed? A Case Report of Caudate Nucleus Infarct

by Sangsoo Lee, MD; Dae Yoon Kim, MD; Jung Soo Kim, MD; Sainath Manda, MD; Lilia Danilov, MD; Mostafa El-Refai, MD; and Steven Lippmann, MD Dr. Lee is from the

The Blood Brain Barrier and the Role of Cytokines in Neuropsychiatry

by Atmaram Yarlagadda, MD; Elizabeth Alfson, BA; and Anita H. Clayton, MD Dr. Yarlagadda is from Newport News, Virginia, Ms. Alfson is from Charlottesville, Virginia, and Dr. Clayton is Professor,

Cranial Nerves III, IV, and VI: Oculomotor Function

by Richard D. Sanders, MD, and Paulette Marie Gillig, MD, PhD Dr. Sanders is Associate Professor, Departments of Psychiatry and Neurology, Boonshoft School of Medicine, Wright State University, and Ohio

Brain and Behavior

by Assad Meymandi, MD, PhD, DLFAPA Dr. Meymandi is in private practice as a psychiatrist and neurologist and serves as an adjunct professor of psychiatry at the University of North

Cranial Nerve I: Olfaction

by Richard D. Sanders, MD, and Paulette Marie Gillig, MD, PhD Dr. Sanders is an Associate Professor in the Departments of Psychiatry and Neurology, Boonshoft School of Medicine and Wright

Thermoregulation and the Role of Calcium Signalling in Neurotransmission

by Atmaram Yarlagadda, MD, and Anita H. Clayton, MD Dr. Yarlagadda is from Newport News, Virginia, and Dr. Clayton is Professor, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia,

Beyond Informed Consent: The Ethics of Informing, Anticipating, and Warning

by Edmund Howe, MD, JD Dr. Howe is Professor, Department of Psychiatry, Director, Programs in Medical Ethics, and Senior Scientist, Center for the Study of Traumatic Stress, Uniformed Services University

Baby Stimuli and the Parent Brain: Functional Neuroimaging of the Neural Substrates of Parent-Infant Attachment

by James E. Swain, MD, PhD Yale Child Study Center, Program for Risk, Resilience and Recovery, New Haven, Connecticut

Biomarkers for the Identification and Treatment of Dementia

by Steven D. Targum, MD Dr. Targum is an executive-in-residence at Oxford BioScience Partners and on the faculty of the Department of Psychiatry at the Massachusetts General Hospital. Dr. Targum

Blood Brain Barrier: The Role of Calcium Homeostasis

by Atmaram Yarlagadda, MD; Shaifali Kaushik, MD; and Anita H. Clayton, MD Dr. Yarlagadda is from the Clinical Associates of Tidewater in Newport News, Virginia; Dr. Shaifali is Associate Professor,

Revisiting the Clinical Utility of Cytochrome p450 in Practice

by Andrew A. Nierenberg, MD; and Steven D. Targum, MD Dr. Targum is on the editorial board of Psychiatry 2007. Presently, he is Chief Medical Officer at Brain Cells Inc.,

Blood Brain Barrier: The Role of Pyridoxine

by Atmaram Yarlagadda, MD; and Anita H. Clayton, MD Dr. Yarlagadda is from McDonald Army Health Center, Fort Eustis, Virginia, and from Clinical Associates of Tidewater, Newport News, Virginia; and

Alzheimer’s Therapies

by Elisa F. Cascade; Amir H. Kalali, MD; and Edmund Howe, MD, JD Ms. Cascade is Vice President, Strategic Research and Safety, Quintiles Inc., Falls Church, Virginia; Dr. Kalali is

Initial Screening of Patients for Alzheimer’s Disease and Minimal Cognitive Impairment

by Edmund Howe, MD, JD Dr. Howe is Professor, Department of Psychiatry, and Director, Programs in Medical Ethics, Uniformed Services University of the Health Sciences, Bethesda, Maryland

Blood Brain Barrier: The Role of GAD Antibodies in Psychiatry

by Atmaram Yarlagadda, MD; Badalin Helvink, MD; Caroline Chou, MD; and Anita H. Clayton, MD Dr. Yarlagadda is from McDonald Army Health Center, Fort Eustis, Virginia; Dr. Helvink was with