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Category: Current Issue

Molecular and Cellular Mechanisms Underlying Neurological and Neuropsychological Manifestations of COVID-19

Innov Clin Neurosci. 2025;22(10–12):14–23. by Samaneh Ghorbani Shirkouhi, MSc; Seyed Sepehr Khatami, MD; Zohair Niroomand, MD; Saeed Sadigh-Eteghad, PhD; Shahrokh Yousefzadeh-Chabok, MD; and Sasan Andalib, PhD Ms. Ghorbani Shirkouhi is

Genetic Disorders That Confer Risk for the Development of Psychosis and White Matter Hyperintensities on T2-weighted Imaging: A Practical Guide for Psychiatrists

Innov Clin Neurosci. 2025;22(10–12):24–32. by Mark A. Colijn, MD, MSc, FRCPC, UCNS Dr. Colijn is with the Department of Psychiatry, Mathison Centre for Mental Health Research and Education, and Hotchkiss

Validation of a Pediatric Cognitive Assessment Tool to Advance Knowledge on Children’s Cognitive Development, Health Risk Factors, and Health-promoting Interventions in Sub-Saharan Regions

Innov Clin Neurosci. 2025;22(10–12):33–51. by Franco Di Cesare, MD; Cristiana Di Carlo, MPhil; and Leonardo Di Cesare, MD All authors are with Leoben Research Aurora in San Vincenzo Valle Roveto

Neurocognitive Disorders: Systematic Review of Approved (2008–2024) and Pipeline Phase III Medications

Innov Clin Neurosci. 2025;22(10–12):57–71. by Jayant Totlani, DO; Muhammad Arsalan Bashir, MBBS; Laurel Tay, BA; Ashley Ngor, BS; Alexander J. Steiner, PsyD; Drew Hirsch, BS; Lorena Contreras, MA; Sabrina Renteria,

Bias in Assessing Decision-making Capacity in Patients with Serious Mental Illness in Hospital Settings

Innov Clin Neurosci. 2025;22(10–12):52–56. by Alexandria Nasr, MD; Larrilyn Grant, MD; Jennifer Golida, BS; and Bailey Hangen, BS, MS All authors are affiliated with the Boonshoft School of Medicine at

Adaptation, Translation, and Validation of the Perceived Parenting Style Scale in Pakistan Using ITC Protocol

Innov Clin Neurosci. 2025;22(10–12):72–77. by Anam Shahid, PhD; Alia Asmat, PhD; and Sunny Singh, MD Dr. Shahid and Dr. Singh are with the Nova Scotia Health Authority in Sydney, Nova

Selected Abstracts from CNS Summit 2025

Innov Clin Neur. 2025;22(10–12):78–85. November 2–5, 2025 in Boston, Massachusetts. Artificial intelligence (AI)/machine-based learning Digital phenotyping with real-world data to identify candidates for anti-CGRP migraine treatment Presenters: Giorgio Pietro Biondetti;

Risk Management: I’ve Been Sued, Now What! Part 4: Closing Statements, Jury Deliberations, Verdicts, Judgments, and Appeals

Innov Clin Neurosci. 2025;22(10–12):86–87. by Justin Pope, JD Mr. Pope is Associate Director of Risk Management at Professional Risk Management Services (PRMS). FUNDING: No funding was provided for the preparation

“You’re Not Crazy”: A Case of New-onset AI-associated Psychosis

Due to the timely nature of this topic, we are providing an advanced release of this article, ahead of the October-December 2025 issue publication. This article is subject to changes

Can You Properly Manage Delusional Parasitosis?

Innov Clin Neurosci. 2025;22(7–9):40–41. by Adil Tumbi, MD; Amit Mistry, MD; BreAnna-Anh Le, BS; and Steven Lippmann, MD Drs. Tumbi and Mistry are with the Oklahoma City Veteran Affairs Health

Risk Management: I’ve Been Sued, Now What! Part 3: Litigation Process—Jury Selection, Opening Statement, and Calling Witnesses

Innov Clin Neurosci. 2025;22(7–9):42–43. by Akemini “Kem” Isang, RN, JD Ms. Isang is a Risk Manager at Professional Risk Management Services (PRMS). FUNDING: No funding was provided for the preparation

Letter to the Editor: Whether Telerehabilitation is Actually Beneficial in Iatrogenic Facial Palsy Needs to be Confirmed by Prospective, Multicenter, Controlled Studies

Funding/financial disclosures. The authors have no conflicts of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2023;20(10–12):8.

Left Ventricular Noncompaction Cardiomyopathy Diagnosis in a Patient Presenting with Epileptic Seizure: A “Double-edged Sword”

by Eirini Beneki, MD, MSc, PhD; Kyriakos Dimitriadis, MD, PhD; Konstantinos Tsatiris, MD, MSc; Konstantina Aggeli, MD, PhD; and Konstantinos Tsioufis, MD, PhD Drs. Beneki, Dimitriadis, Aggeli, and Tsioufis are

Outpatient Pharmacogenomic Screenings to Prevent Addiction, Overdose, and Suicide

by Atmaram Yarlagadda, MD; Kevin Swift, PhD; Nabarun Chakraborty, MS, MBA; Rasha Hammamieh, PhD; Amina Abubakar, PharmD; Marianna Wilbur, PharmD; and Anita H. Clayton, MD Dr. Yarlagadda is Installation Director

Impact of COVID-19 on the Mental Health of Psychiatric Inpatients

by Samara White, PharmD; Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP; Eileen Trigoboff, PMHCNS-BC, DNS, DABFN; Lucy Keers, PharmD; and Chloe Matecki, PharmD All authors are with Department of

Impact of the Medication Shortages on Psychiatric Patients: Exploring the Consequences of Lorazepam Injection Scarcity

by Yael Marks, BS, PharmD; Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP; and Chloe Matecki, PharmD All authors are with Department of Pharmacy Practice, State University of New York

Addressing Structural Racism in Child and Adolescent Psychiatry in Psychotherapy

by Sydnee Akubuiro, MD; Wendy Clay, MPH, MD; Suzie Nelson, MD; and Allison E. Cowan, MD Dr. Akubuiro is with Department of Psychiatry and Behavioral Sciences, Emory University School of

The Challenge of Somatic Variants in Focal Cortical Dysplasia

by Joana Jesus-Ribeiro, PhD; Luís Miguel Pires, MS; Ilda Patrícia Ribeiro, PhD; Olinda Rebelo, MD; Ricardo Pereira, MD; Francisco Sales, MD; Isabel Santana, PhD; António Freire, PhD; and Joana Barbosa

Morphological and Functional Changes of Cerebral Cortex in Autism Spectrum Disorder

by Leong Tung Ong, MBBS, and Si Wei David Fan, MBBS Both authors are with Faculty of Medicine, University of Malaya in Kuala Lumpur, Malaysia. Funding: No funding was provided

Treating Psychiatric Symptoms in Persistent Postural Perceptual Dizziness

by Jonathan R. Scarff, MD, and Steven Lippmann, MD Dr. Scarff is Staff Psychiatrist, Veterans Affairs Medical Center in Lexington, Kentucky. Dr. Lippmann is Professor Emeritus, University of Louisville School

Risk Management: Pop Quiz

by Donna Vanderpool, MBA, JD Ms. Vanderpool is Director of Risk Management at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures:

Risk Management: Pop Quiz Answers

by Donna Vanderpool, MBA, JD Ms. Vanderpool is Director of Risk Management at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures:

Back to the Future: An Appraisal of the Role of Osteopathic Manipulative Treatment in Patients with Neurological Diseases

by Mirjam Bonanno, MSc, and Rocco Salvatore Calabrò, MD, PhD Ms. Bonanno and Dr. Calabrò are with Neurorehabilitation Unit, IRCCS Neurolesi Center “Bonino-Pulejo” in Messina, Italy. Funding: No funding was

WORDS: A New Verbal Memory Test to Evaluate Cognitive Health in a Zambian School-aged Population

by Franco Di Cesare, MD; Giulia Piccinini, MD; Cristiana Di Carlo, MPhil; and Leonardo Di Cesare, MD Drs. F. Di Cesare, Di Carlo, and L. Di Cesare are with Leoben

Innovative Technologies in CNS Trials: Promises and Pitfalls for Recruitment, Retention, and Representativeness

by Jacqueline Lutz, PhD; Abhishek Pratap, PhD; Eric J. Lenze, MD; Durga Bestha, MD; Jessica M. Lipschitz, PhD; Stella Karantzoulis, PhD; Uma Vaidyanathan, PhD; Jessica Robin, PhD; William Horan, PhD;

Exploring the Complex Relationship Between Antiepileptic Drugs and Suicidality: A Systematic Literature Review

by Aksha M. Memon, MBBS, MD, MPH; Jigar Katwala, MBBS, MD; Clarice Douille, BS; Caitlin Kelley, BS; and Varun Monga, MD Dr. Memon is with Creighton University School of Medicine

Risk Management: Treating Patients at Risk for Suicide: Part 2

by Akemini “Kem” Isang, RN, JD Ms. Isang is a Risk Manager at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures:

Letter to the Editor: Olanzapine-induced Endoplasmic Reticulum Stress Induces Atypical Diabetes and Diabetic Ketoacidosis

Funding/financial disclosures. The author has no conflicts of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(10–12):8–9.

Major Depressive Disorder, Suicides, and the Role of Dimensional Psychiatry for Triaging in Primary Care Settings: A Case Series Retroanalysis

by Atmaram Yarlagadda, MD; Adrian R. Johnson, LCSW, MSW; Cheyenne M. Bickerstaff, BS; Joseph R. Yancey, MD, MBA; Samuel L. Preston, DO; Liquori L. Etheridge, LCSW; Michelle Maddalozzo, LCSW; Samuel

Executive Functioning in Children and Adolescents with ADHD and Disruptive Behavior Disorders

by Rosa Elena Ulloa Flores, MD, PhD; Ricardo Díaz Sánchez, BS; Francisco R. de la Peña, MD, MS; Marcos F. Rosetti Sciutto, PhD; Lino Palacios Cruz, MD, PhD; and Pablo

Olfactory Dysfunction in Incidental Lewy Body Disease and Parkinson’s Disease: An Update

by Shemonti Hasan, MD; Charles H. Adler, MD, PhD; Nan Zhang, MS; Geidy E. Serrano, PhD; Lucia I. Sue, BS; Holly A. Shill, MD; Shyamal H. Mehta, MD, PhD; Thomas

Impact of COVID-19 Pandemic on Psychiatric Patients at Clinical Trial Sites

by Maria Fe Garcia-Rada, MPS, and Robert E. Litman, MD Ms. Garcia-Rada and Dr. Litman are with CenExel CBH Health in Gaithersburg, Maryland. Dr. Litman is with Georgetown University Medical

Stroop Test for Parkinson’s Disease with Deep Brain Stimulation: A Systematic Review

by Amer Cavalheiro Hamdan, PhD, and Mariana Drabik Vieira, MSc Dr. Hamdan is with the Graduate Program in Psychology, Department of Psychology, Federal University of Parana in Curitiba, Brazil. Dr.

Psychotherapy for Adult ADHD

by Kari Harper, MD, and Julie P. Gentile, MD, MBA Dr. Harper is Assistant Professor and Dr. Gentile is Professor and Chair of the Department of Psychiatry at Wright State

Play Therapy via Telemedicine in a Child with Sudden-onset Emotional Disorder During the COVID-19 Lockdown Period: A Case Report

by Swapnajeet Sahoo, MD; Diksha Sachdeva, MPhil; Sana Yumnam, MD; Ruchita Shah, MD; Aseem Mehra, MD; and Sandeep Grover, MD All authors are with the Department of Psychiatry, Post Graduate

Virtual and Augmented Reality-based Treatments for Phantom Limb Pain: A Systematic Review

by Andrew Yimu Vassantachart, MD; Elizabeth Yeo, MD; and Brian Chau, MD Dr. Vassantachart is with Loma Linda University School of Medicine in Loma Linda, California. Dr. Yeo is with

Risk Management: Top 25 Tips to Reduce Clinicians’ Stress Levels

by Donna Vanderpool, MBA, JD Ms. Vanderpool is the Director of Risk Management at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article.

Letter to the Editor: Steroid Management in a Patient with Myasthenia Gravis Undergoing COVID-19 Vaccination

Funding/financial disclosures. The authors have no conflict of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(7–9):8.

Post-stroke Sexual Dysfunction in Men: Epidemiology, Diagnostic Work-up, and Treatment

by Rocco Salvatore Calabrò, MD, PhD Dr. Calabrò is with IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Funding: No funding was provided for this article. Disclosures: The author has no

Pre-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorder: Results of a Lebanese Case-control Study

by Aline Hajj, PharmD, PhD; Souheil Hallit, PharmD, MSc, MPH, PhD; Rouba El-Khatib, PharmD; Sandra Abi Haidar, PharmD; Fabienne Hajj Moussa Lteif, MSc; Layal Hajj, MSc; Maguy Moudawar, MSc; and

Psychotherapy for Violent Behavior in Children and Adolescents

by Kari Harper, MD, and Julie P. Gentile, MD, MBA Dr. Harper is Assistant Professor and Assistant Training Director of Child/Adolescent Fellowship at Wright State University in Dayton, Ohio. Dr.

Quantitative Characterization of the Smoothness of Extended-release Methylphenidate Pharmacokinetic Profiles

by Michelle D. Po, PhD; Roberto Gomeni, PhD, HDR, FCP; and Bev Incledon, PhD Dr. Po is with Highland Therapeutics Inc. in Toronto, Ontario, Canada. Dr. Gomeni is with PharmacoMetrica

A Cannabinoid Hypothesis of Schizophrenia: Pathways to Psychosis

by Rachel Little, MA, and Dale D’Mello, MD Ms. Little is a science writer in Lansing, Michigan. Dr. D’Mello is Associate Professor Emeritus with the Department of Psychiatry at Michigan

Self-administration of Psilocybin in the Setting of Treatment-resistant Depression

by Ashley Lyons, MPA, PA-C Dr. Lyons is a Doctor of Medical Science in Psychiatry at Rocky Mountain University School of Health Professions in Norfolk, Virginia. Funding: No funding was

Noah Syndrome: A Review Regarding Animal Hoarding with Squalor

by Leonor Moreira Abreu, MD, MSc, and João Gama Marques, MD, MSc, PhD Dr. Moreira Abreu and Prof. Gama Marques are with Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade

EcoMeditation Modifies Brain Resting State Network Activity

by Peta Stapleton, PhD; Dawson Church, PhD; Oliver Baumann, PhD; and Debbie Sabot, BA, Grad Dip Psych Drs. Stapleton and Baumann and Ms. Sabot are with the School of Psychology,

Abnormality of Contingent Negative Variation Correlates with Parkinson’s Disease Severity

by Plamen Tzvetanov, MD, Phd, DSc, FRCP; Ivan Lisichkov, MD, PhD; Rossen T. Rousseff MD, PhD; Vishwajit Hegde, MD, FRCP; and Sergey Kostadinov, MD, PhD Prof. Tzvetanov is with the

Risk Management: On the Record: Documentation of Psychiatric Treatment

by Ann L. McNary, JD Ms. McNary is Senior Risk Manager at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures: The

Letter to the Editor: Innovative Rehabilitation Technologies in the COVID-19 Era: Two Sides of the Same Coin

Funding/financial disclosures. The authors have no conflict of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(4–6):8–9.

Letter to the Editor: Orthognathic Surgery for Patients with Neurodevelopmental Disorders Requires Careful Decision-making by a Multidisciplinary Team

Funding/financial disclosures. The authors have no conflict of interest relevant to the content of this letter. No funding was received for the preparation of this letter. Innov Clin Neurosci. 2022;19(4–6):9–10.

Use of Repetitive Transcranial Magnetic Stimulation in Child Psychiatry

by Anca Maria Bejenaru, MD, and Narpinder Kaur Malhi, MD Drs. Bejenaru and Malhi are with the Department of Psychiatry and Behavioral Health, Christiana Care in Wilmington, Delaware. Funding: No

Gender-affirming Care for Transgender Patients

by Nita Bhatt MD, MPH; Jesse Cannella, MSIII; and Julie P. Gentile, MD, MBA Dr. Bhatt is Associate Director of Medical Student Education and Associate Professor in the Department of

Social Neuroscience and Mental Processes: How Does Our Brain Process Social Information?

by Gabriela Correia Teixeira, Graduating in Psychology; Ana Maria Mazon Araújo, Graduating in Psychology; and Michael Jackson Oliveira de Andrade, Doctor of Psychology All authors are with the Laboratory of

SIBAT—A Computerized Assessment Tool for Suicide Ideation and Behavior: Development and Psychometric Properties

by Larry Alphs, MD, PhD; Dong-Jing Fu, MD, PhD; David Williamson, PhD; Carol Jamieson, BSc, FIBMS; John Greist, MD; Magdalena Harrington, PhD; Jean-Pierre Lindenmayer, MD; Cheryl McCullumsmith, MD, PhD; David

Acute Thalamic Ischemic Stroke in an Older Patient Newly Vaccinated with COVID-19 Vaccine Based on Adenoviral Vectors

by Kelly Mesa-Gamarra, MD; Mario Pineda-Paternina, MD; Edgar Castillo, MD; Loida Camargo, MD, MSc; Alexander Pabón, MD; Jorge Herrera-Pino, MD, PhD; Nicole Caldichoury, MSc; Pascual A. Gargiulo, MD, PhD; Yuliana

Comparative Analysis of Treatment Outcomes in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab, Azathioprine, and Mycophenolate Mofetil: A Systematic Review and Meta-analysis

by Christy Magdalena, MD, MRes; Audrey Clarissa, MD, MRes; and Nathania Sutandi, MD, MRes All authors are with Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital in Jakarta,

Implementing Digital Technologies in Clinical Trials: Lessons Learned

by Georgia Mitsi, PhD; Todd Grinnell, BA; Suzanne Giordano, PhD; Thomas Goodin, Phd; Shahin Sanjar, PhD; Elizabeth Marble, BS; and Andrei Pikalov, MD, PhD All authors are with Sunovion Pharmaceuticals

Correlation Between CD133+ Stem Cells and Clinical Improvement in Patients with Autism Spectrum Disorders Treated with Intrathecal Bone Marrow-derived Mononuclear Cells

by Laura Villarreal-Martinez, MD; Laura Elia MartÍnez-Garza, MD; Iram Pablo Rodriguez-Sanchez, MD; Neri Alvarez-Villalobos, MD; Fernando Guzman-Gallardo, MD; Sulia Pope-Salazar, MD; Cynthia Salinas-Silva, MD; Maria Guadalupe Cepeda-Cepeda, MD; Alejandra Garza-Bedolla,

Risk Management: Adjusting to Your New Normal

by Ann L. McNary, JD Ms. McNary is Senior Risk Manager at Professional Risk Management Services (PRMS). Funding: No funding was provided for the preparation of this article. Disclosures: The

Cerebellar Atrophy Associated with Primary Sjögren’s Syndrome: Diagnosis, Therapy, and Virtual Reality Rehabilitation: A Case Report

by Emanuele Lo Voi, PhD; Giorgio Carmelo Basile, MD; Alessia Bramanti, PhD; Giuseppe Paladina, Annalisa Militi, MD; Daniele Bruschetta, MD; Angelo Alito,MD; Filippo Cavallaro; Salvatore Bertino, MD; and Demetrio Milardi,