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Comparative Analysis of Treatment Outcomes in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab, Azathioprine, and Mycophenolate Mofetil: A Systematic Review and Meta-analysis

by Christy Magdalena, MD, MRes; Audrey Clarissa, MD, MRes; and Nathania Sutandi, MD, MRes All authors are with Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital in Jakarta,

Implementing Digital Technologies in Clinical Trials: Lessons Learned

by Georgia Mitsi, PhD; Todd Grinnell, BA; Suzanne Giordano, PhD; Thomas Goodin, Phd; Shahin Sanjar, PhD; Elizabeth Marble, BS; and Andrei Pikalov, MD, PhD All authors are with Sunovion Pharmaceuticals

The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review

by Muhannad M. Alsharidah, MBBS; Mohammad Uzair, BS; Sarah S. Alseneidi, MBBS; Afnan A. Alkharan, MBBS; Reem Fahd Bunyan, MBBS; and Shahid Bashir, PhD Drs. Alsharidah and Alseneidi are with

Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation Approach

by Antonino Naro, MD, PhD; Luana Billeri, MSc; Paola Lauria, MSc; Alfredo Manuli, MSc; and Rocco Salvatore Calabrò, MD Drs. Naro and Calabrò, Ms. Billeri, Ms. Lauria, and Mr. Manuli

Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications

by Loredana Raciti, MD, PhD; Francesca Antonia Arcadi, MD, PhD; and Rocco Salvatore Calabrò, MD, PhD Drs. Raciti, Arcadi, and Calabrò are with IRCCS Centro Neurolesi “Bonino Pulejo” in Messina,

Making Sense of the Matrix: A Qualitative Assessment and Commentary on Connecting Psychiatric Symptom Scale Items to the Research Domain Criteria (RDoC)

by Leslie Citrome, MD, MPH; Anissa Abi-Dargham, MD; Robert M. Bilder, PhD; Ruth A. Duffy, PhD; Boadie W. Dunlop, MD; Philip D. Harvey, PhD; Diego A. Pizzagalli, PhD; Carol A.

Selective Serotonin Reuptake Inhibitors (SSRIs) and Their Effect on Patient Aggression in Adult Patients in a State Psychiatric Facility: A Retrospective Analysis

by Carolyn O’Donnell, PharmD; Tammie Lee Demler, PharmD, MBA, BCGP, BCPP; and Eileen Trigoboff, RN, PMHCNS-BC, DNS, DABFN; Drs. O’Donnell, Demler, and Trigoboff are with the State University of New

Pimavanserin in the Treatment of Parkinson’s Disease Psychosis: Meta-analysis and Meta-regression of Randomized Clinical Trials

by Zeeshan Mansuri, MD, MPH; Abhishek Reddy, MD; Ramu Vadukapuram, MD; Chintan Trivedi, MD, MPH; and Amy Amara, MD, PhD Dr. Mansuri is with the Department of Psychiatry, Boston Children’s

Using Artificial Intelligence-based Methods to Address the Placebo Response in Clinical Trials

by Erica A. Smith, PhD; William P. Horan, PhD; Dominique Demolle, PhD; Peter Schueler, MD; Dong-Jing Fu, MD, PhD; Ariana E. Anderson, PhD; Joseph Geraci, MSc, PhD; Florence Butlen-Ducuing, MD,

Letter to the Editor: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem

Innov Clin Neurosci. 2021;18(10–12):8. Dear Editor: Primary central nervous system (CNS) lymphoma (pCNL) is a rare neoplasia predominantly of the brain. Histologically, most of these neoplasias are diffuse large B-cell

Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report

by Stefania Brotini, MD Dr. Brotini is with the Movement Disorder Center, Department of Neurology, San Giuseppe Hospital in Empoli, Florence, Italy FUNDING: No funding was provided for this study.

Clinician- and Patient-reported Endpoints in CNS Orphan Drug Clinical Trials: ISCTM Position Paper on Best Practices for Endpoint Selection, Validation, Training, and Standardization

by Joan Busner, PhD; Gahan Pandina, PhD; Silvia Zaragoza domingo PhD; Anna-Karin Berger PhD; Maria T. Acosta, MD; Nahome Fisseha, PharmD; Joseph Horrigan, MD; Jelena Ivkovic, MD; William Jacobson, PhD;

Is Neuromuscular Electrical Stimulation Effective in Treating Severe Dysarthria: Insights from a Case Study

by Matteo Berenati, MSc; Antonino Naro, MD, PhD; Cinzia Calabrò, MSc; Michele Torrisi, PsyD; Salvatore Massimiliano Cardali, MD; and Rocco Salvatore Calabrò, MD, PhD Mr. Berenati, Ms. C. Calabrò, and

Sexual Function and Disability in the Neurorehabilitation Setting: An Urgent Need for a Multidisciplinary Approach

by Rocco Salvatore Calabrò, MD, PhD, and Alfredo Manuli, MSc Dr. Calabrò is with the IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Mr. Manuli is with the Physical Medicine and